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PMID: 16823477 Published · ppublish English Journal Article Review

Inflammation and insulin resistance.

The Journal of clinical investigation ·Vol. 116 ·No. 7 ·2006-07-00 ·Pages 1793-801

Shoelson SE, Lee J, Goldfine AB

Abstract

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.

MeSH Terms
Adipocytes/metabolism Anti-Inflammatory Agents/metabolism,therapeutic use Clinical Trials as Topic Diabetes Mellitus, Type 2/drug therapy,immunology Humans Inflammation/drug therapy,immunology Insulin Resistance/immunology Liver/metabolism Obesity Signal Transduction/physiology
Chemicals
Anti-Inflammatory Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shoelson Steven E
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA. [email protected]
Lee Jongsoon
Goldfine Allison B
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI29069
Email
[email protected]
Published
2006-07-00
Pages
1793-801
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1483173
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1172/JCI29069 PMC Full Text View journal details
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