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PMID: 16840683 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Comment

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens" and "Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans".

Science (New York, N.Y.) ·Vol. 313 ·No. 5784 ·2006-07-14 ·Pages 172; author reply 172

Currat M, Excoffier L, Maddison W, Otto SP, Ray N, Whitlock MC, Yeaman S

Abstract

Mekel-Bobrov et al. and Evans et al. (Reports, 9 Sept. 2005, p. 1720 and p. 1717, respectively) examined sequence data from modern humans within two gene regions associated with brain development, ASPM and microcephalin, and concluded that selection of these genes must be ongoing. We show that models of human history that include both population growth and spatial structure can generate the observed patterns without selection.

MeSH Terms

Adaptation, Biological Biological Evolution Brain Cell Cycle Proteins Cytoskeletal Proteins Demography Founder Effect Gene Frequency Haplotypes Humans Models, Theoretical Nerve Tissue Proteins/genetics Organ Size Population Density Population Growth Selection, Genetic Sequence Analysis, DNA

Chemicals

ASPM protein, human Cell Cycle Proteins Cytoskeletal Proteins MCPH1 protein, human Nerve Tissue Proteins

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Currat Mathias

Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Excoffier Laurent

Maddison Wayne

Otto Sarah P

Ray Nicolas

Whitlock Michael C

Yeaman Sam

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1122822

Published

2006-07-14

Pages

172; author reply 172

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentOn

PMID: 16151009

CommentOn

PMID: 16151010

External Links

PubMed source DOI: 10.1126/science.1122822 View journal details

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Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens" and "Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans".

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