Cyclic AMP induces ultrastructural differentiation of normal adult human adrenocortical cells cultured in vitro.

The American journal of anatomy ·Vol. 142 ·No. 4 ·1975-04-00 ·Pages 533-8

Armato U, Nussdorfer GG, Mazzocchi G, Andreis PG, Draghi E

Abstract

Electron microscopic studies have revealed that cyclic AMP, like ACTH, induces structural differentiation of adult human adreno-cortical cells cultured in vitro. These findings support the hypothesis that cyclic AMP can function as an intracellular mediator of the action of ACTH on the human adrenal gland.

MeSH Terms

Adrenal Cortex/drug effects,ultrastructure Adrenal Glands/ultrastructure Adrenocorticotropic Hormone/metabolism Adult Biopsy Culture Techniques Cyclic AMP/pharmacology Endoplasmic Reticulum/ultrastructure Golgi Apparatus/ultrastructure Humans Microscopy, Electron Mitochondria/ultrastructure

Chemicals

Adrenocorticotropic Hormone Cyclic AMP

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Armato U

Nussdorfer G G

Mazzocchi G

Andreis P G

Draghi E

Article Info

Journal

The American journal of anatomy

Abbr.

Am J Anat

ISSN

0002-9106

DOI

10.1002/aja.1001420411

Published

1975-04-00

Pages

533-8

Language

English

Region

United States

NLM ID

0376312

Subset

External Links

PubMed source DOI: 10.1002/aja.1001420411 View journal details

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Cyclic AMP induces ultrastructural differentiation of normal adult human adrenocortical cells cultured in vitro.

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