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PMID: 16877336 Published · ppublish English Journal Article

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.

The American journal of pathology ·Vol. 169 ·No. 2 ·2006-08-00 ·Pages 338-46

Bryder D, Rossi DJ, Weissman IL

Abstract

The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.

MeSH Terms
Animals Cell Proliferation Hematopoietic Stem Cells/cytology Humans Models, Biological Organ Specificity
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bryder David
Stanford University School of Medicine, B257 Beckman Center, Stanford, CA 94305-5323, USA.
Rossi Derrick J
Weissman Irving L
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.2353/ajpath.2006.060312
Published
2006-08-00
Pages
338-46
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1698791
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.2353/ajpath.2006.060312 PMC Full Text View journal details
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