Mapping and characterization of neutralizing epitopes of glycoproteins gIII and gp50 of the Indiana-Funkhauser strain of pseudorabies virus.

Archives of virology ·Vol. 110 ·No. 1-2 ·1990-00-00 ·Pages 137-42

Coe NE, Mengeling WL

Abstract

Neutralizing monoclonal antibodies directed against pseudorabies glycoproteins gIII or gp50 were produced. Using these antibodies in competitive binding ELISAs, three overlapping epitopes for gp50 and two nonoverlapping epitopes for gIII were mapped.

MeSH Terms

Antibodies, Monoclonal/analysis,isolation & purification Antibodies, Viral/analysis Antigens, Viral/genetics,immunology Binding, Competitive Chromosome Mapping Enzyme-Linked Immunosorbent Assay Epitopes/genetics,immunology Glycoproteins/genetics,immunology Herpesvirus 1, Suid/genetics,immunology Neutralization Tests Viral Envelope Proteins/genetics,immunology Viral Proteins/genetics,immunology

Chemicals

Antibodies, Monoclonal Antibodies, Viral Antigens, Viral Epitopes Glycoproteins Viral Envelope Proteins Viral Proteins pseudorabies virus glycoproteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Coe N E

National Animal Disease Center, USDA, Ames, Iowa.

Mengeling W L

References (8)

8 references, click to expand

Identification of the pseudorabies virus glycoprotein gp50 as a major target of neutralizing antibodies.
Arch Virol. 1988;99(1-2):45-56 PMID: 2833202
Epitope analysis of human cytomegalovirus glycoprotein complexes using murine monoclonal antibodies.
Virology. 1988 Jun;164(2):362-72 PMID: 2453096
A vaccine strain of pseudorabies virus with deletions in the thymidine kinase and glycoprotein X genes.
Am J Vet Res. 1987 Nov;48(11):1577-83 PMID: 2829665
Analysis of pseudorabies virus glycoprotein gIII localization and modification by using novel infectious viral mutants carrying unique EcoRI sites.
J Virol. 1987 Oct;61(10):2962-72 PMID: 3041015
Evaluation of pseudorabies virus glycoprotein gp50 as a vaccine for Aujeszky's disease in mice and swine: expression by vaccinia virus and Chinese hamster ovary cells.
J Virol. 1987 Dec;61(12):3977-82 PMID: 2824827
Production and characterization of monoclonal antibodies directed against pseudorabies virus.
Virus Res. 1985 Dec;4(1):19-29 PMID: 3002067
Efficacy of an inactivated virus vaccine for prevention of porcine parvovirus-induced reproductive failure.
Am J Vet Res. 1979 Feb;40(2):204-7 PMID: 464358
Size and antigenic comparisons among the structural proteins of selected autonomous parvoviruses.
J Gen Virol. 1988 Apr;69 ( Pt 4):825-37 PMID: 3356979

Article Info

Journal

Archives of virology

Abbr.

Arch Virol

ISSN

0304-8608

DOI

10.1007/BF01310710

Published

1990-00-00

Pages

137-42

Language

English

Region

Austria

NLM ID

7506870

Subset

External Links

PubMed source DOI: 10.1007/BF01310710 View journal details

Analysis Services

Mapping and characterization of neutralizing epitopes of glycoproteins gIII and gp50 of the Indiana-Funkhauser strain of pseudorabies virus.

Contact

WeChat Official Account