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PMID: 16901411 Published · ppublish English Journal Article Review

High-density lipoprotein: is it always atheroprotective?

Current atherosclerosis reports ·Vol. 8 ·No. 5 ·2006-09-00 ·Pages 405-11

Ansell BJ, Fonarow GC, Fogelman AM

Abstract

High-density lipoproteins (HDLs) are appropriately recognized for their many atheroprotective functions, including reverse cholesterol transport, as well as antioxidant, anti-inflammatory, and antithrombotic effects. Furthermore, the inverse relationship between HDL cholesterol and atherosclerosis is well documented in many populations. However, there is an increasing body of evidence that there are circumstances in which HDL may not be protective, and may in fact paradoxically promote vascular inflammation and oxidation of low-density lipoproteins. Recent studies have provided insight as to specific chemical modifications and structural changes within HDL associated with this phenotype. The presence of proinflammatory HDL coincides with conditions associated with chronic systemic inflammation, including atherosclerosis.

MeSH Terms
Anticholesteremic Agents/therapeutic use Atherosclerosis/blood,prevention & control Cholesterol, HDL/blood Disease Progression Humans Risk Factors
Chemicals
Anticholesteremic Agents Cholesterol, HDL
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ansell Benjamin J
Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 525, Los Angeles, CA 90095, USA. [email protected]
Fonarow Gregg C
Fogelman Alan M
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Article Info
Journal
Current atherosclerosis reports
Abbr.
Curr Atheroscler Rep
ISSN
1523-3804
DOI
10.1007/s11883-006-0038-4
Email
[email protected]
Published
2006-09-00
Pages
405-11
Language
English
Region
United States
NLM ID
100897685
Subset
IM
External Links
PubMed source DOI: 10.1007/s11883-006-0038-4 View journal details
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