Home LiteratureArticle Details
PMID: 16905530 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mechanisms in eukaryotic mismatch repair.

The Journal of biological chemistry ·Vol. 281 ·No. 41 ·2006-10-13 ·Pages 30305-9

Modrich P

Abstract

暂无摘要

MeSH Terms
Adenosine Triphosphatases/metabolism Base Pair Mismatch DNA Damage DNA Repair Escherichia coli/metabolism Escherichia coli Proteins/metabolism Exodeoxyribonucleases/metabolism Humans Hydrolysis Models, Biological MutL Proteins MutS DNA Mismatch-Binding Protein/metabolism
Chemicals
Escherichia coli Proteins MutL protein, E coli Exodeoxyribonucleases exodeoxyribonuclease I Adenosine Triphosphatases MutL Proteins MutS DNA Mismatch-Binding Protein MutS protein, E coli
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Modrich Paul
Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA. [email protected]
References (46)
46 references, click to expand
  1. Evidence for involvement of HMGB1 protein in human DNA mismatch repair.
    J Biol Chem. 2004 May 14;279(20):20935-40 PMID: 15014079
  2. Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol3-01 mutants.
    Mol Cell. 2000 Sep;6(3):593-603 PMID: 11030339
  3. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2.
    Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7487-92 PMID: 9207118
  4. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
    Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13629-34 PMID: 8942985
  5. Human exonuclease I is required for 5' and 3' mismatch repair.
    J Biol Chem. 2002 Apr 12;277(15):13302-11 PMID: 11809771
  6. Differential requirement for proliferating cell nuclear antigen in 5' and 3' nick-directed excision in human mismatch repair.
    J Biol Chem. 2004 Apr 23;279(17):16912-7 PMID: 14871894
  7. Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.
    Nucleic Acids Res. 1998 Aug 15;26(16):3762-8 PMID: 9685493
  8. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains.
    Mol Cell Biol. 2005 Jan;25(1):461-71 PMID: 15601866
  9. DNA mismatch repair: functions and mechanisms.
    Chem Rev. 2006 Feb;106(2):302-23 PMID: 16464007
  10. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair.
    Nucleic Acids Res. 1998 Mar 1;26(5):1173-8 PMID: 9469823
  11. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
    Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):1950-4 PMID: 7892206
  12. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction.
    J Biol Chem. 1993 Jun 5;268(16):11838-44 PMID: 8505312
  13. The multifaceted mismatch-repair system.
    Nat Rev Mol Cell Biol. 2006 May;7(5):335-46 PMID: 16612326
  14. DNA polymerase delta is required for human mismatch repair in vitro.
    J Biol Chem. 1997 Apr 18;272(16):10917-21 PMID: 9099749
  15. Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points.
    Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10156-61 PMID: 8816768
  16. The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae.
    Mol Cell Biol. 1999 Mar;19(3):2000-7 PMID: 10022887
  17. A defined human system that supports bidirectional mismatch-provoked excision.
    Mol Cell. 2004 Jul 2;15(1):31-41 PMID: 15225546
  18. Human mismatch repair: reconstitution of a nick-directed bidirectional reaction.
    J Biol Chem. 2005 Dec 2;280(48):39752-61 PMID: 16188885
  19. Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.
    J Biol Chem. 1999 Nov 5;274(45):32368-75 PMID: 10542278
  20. Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA.
    Oncogene. 2004 Feb 19;23(7):1457-68 PMID: 14676842
  21. Role of DNA mismatch repair defects in the pathogenesis of human cancer.
    J Clin Oncol. 2003 Mar 15;21(6):1174-9 PMID: 12637487
  22. Mismatch repair in human nuclear extracts. Quantitative analyses of excision of nicked circular mismatched DNA substrates, constructed by a new technique employing synthetic oligonucleotides.
    J Biol Chem. 2002 Jul 19;277(29):26136-42 PMID: 12006560
  23. Endonucleolytic function of MutLalpha in human mismatch repair.
    Cell. 2006 Jul 28;126(2):297-308 PMID: 16873062
  24. Cellular DNA replicases: components and dynamics at the replication fork.
    Annu Rev Biochem. 2005;74:283-315 PMID: 15952889
  25. Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
    Cancer Res. 2005 Dec 1;65(23):10759-66 PMID: 16322221
  26. hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.
    EMBO Rep. 2005 May;6(5):438-44 PMID: 15864295
  27. Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex.
    Mol Cell Biol. 1998 Jul;18(7):4177-87 PMID: 9632802
  28. Mechanism of 5'-directed excision in human mismatch repair.
    Mol Cell. 2003 Nov;12(5):1077-86 PMID: 14636568
  29. Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.
    Genes Dev. 2003 Mar 1;17(5):603-14 PMID: 12629043
  30. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells.
    EMBO J. 1999 Dec 1;18(23):6619-29 PMID: 10581236
  31. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
    Science. 1995 Jun 30;268(5219):1912-4 PMID: 7604265
  32. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair.
    J Biol Chem. 1998 Jan 16;273(3):1453-61 PMID: 9430682
  33. Reconstitution of 5'-directed human mismatch repair in a purified system.
    Cell. 2005 Sep 9;122(5):693-705 PMID: 16143102
  34. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
    Cancer Res. 2000 Feb 15;60(4):803-7 PMID: 10706084
  35. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.
    Science. 1995 Feb 24;267(5201):1166-9 PMID: 7855597
  36. Mismatch repair in human nuclear extracts. Time courses and ATP requirements for kinetically distinguishable steps leading to tightly controlled 5' to 3' and aphidicolin-sensitive 3' to 5' mispair-provoked excision.
    J Biol Chem. 2002 Jul 19;277(29):26143-8 PMID: 12006561
  37. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis.
    Cell. 1996 Oct 4;87(1):65-73 PMID: 8858149
  38. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha.
    J Biol Chem. 1998 Jul 31;273(31):19895-901 PMID: 9677427
  39. Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A.
    Mol Cell Biol. 2002 Apr;22(7):2037-46 PMID: 11884592
  40. Evidence for preferential mismatch repair of lagging strand DNA replication errors in yeast.
    Curr Biol. 2003 Apr 29;13(9):744-8 PMID: 12725731
  41. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA.
    Curr Biol. 1996 Sep 1;6(9):1181-4 PMID: 8805365
  42. DNA mismatch repair.
    Annu Rev Biochem. 2005;74:681-710 PMID: 15952900
  43. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
    Science. 1995 Jun 30;268(5219):1909-12 PMID: 7604264
  44. Lynch syndrome genes.
    Fam Cancer. 2005;4(3):227-32 PMID: 16136382
  45. Heteroduplex repair in extracts of human HeLa cells.
    J Biol Chem. 1991 Feb 25;266(6):3744-51 PMID: 1995629
  46. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities.
    J Biol Chem. 1999 Dec 31;274(53):37763-9 PMID: 10608837
Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
0021-9258
DOI
10.1074/jbc.R600022200
Email
[email protected]
Published
2006-10-13
Epub
2006-00-11
Pages
30305-9
Language
English
Region
United States
NLM ID
2985121R
PMCID
PMC2234602
Subset
IM
Grants
NIGMS NIH HHS · R01 GM045190-16 · United States
NCI NIH HHS · P01 CA092584 · United States
Howard Hughes Medical Institute · United States
NCI NIH HHS · P01 CA092584-020005 · United States
NCI NIH HHS · P01 CA92584 · United States
NIGMS NIH HHS · R01 GM45190 · United States
NIGMS NIH HHS · R01 GM045190 · United States
External Links
PubMed source DOI: 10.1074/jbc.R600022200 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2