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PMID: 1691828 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.

Nature ·Vol. 345 ·No. 6270 ·1990-05-03 ·Pages 74-7

Stamenkovic I, Seed B

Abstract

Interaction with antigen-presenting accessory cells is thought to be an important step in B-cell activation, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.

MeSH Terms
Amino Acid Sequence Antigens, CD/genetics,immunology Antigens, Differentiation, B-Lymphocyte/genetics,immunology B-Lymphocytes/immunology Base Sequence Cell Adhesion/immunology Cell Adhesion Molecules Cloning, Molecular Erythrocytes/immunology Immunosorbent Techniques Lectins Molecular Sequence Data Molecular Weight Monocytes/immunology Myelin Proteins Myelin-Associated Glycoprotein Nucleic Acid Hybridization RNA/analysis Receptors, Antigen, B-Cell/immunology Recombinant Proteins/immunology Rosette Formation Sequence Homology, Nucleic Acid Sialic Acid Binding Ig-like Lectin 2 Transfection Tumor Cells, Cultured
Chemicals
Antigens, CD Antigens, Differentiation, B-Lymphocyte Cell Adhesion Molecules Lectins Myelin Proteins Myelin-Associated Glycoprotein Receptors, Antigen, B-Cell Recombinant Proteins Sialic Acid Binding Ig-like Lectin 2 RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stamenkovic I
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Seed B
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/345074a0
Published
1990-05-03
Pages
74-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/345074a0 View journal details
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