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PMID: 1691942 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles.

British journal of pharmacology ·Vol. 99 ·No. 1 ·1990-01-00 ·Pages 194-6

Gillespie JS, Sheng H

Abstract

1. The effects of pyrogallol and hydroquinone on the bovine retractor penis (BRP) and rat anococcygeus muscles to non-adrenergic, non-cholinergic (NANC) nerve stimulation have been examined. Both drugs at a concentration of 10(-4) M significantly reduced the response in the rat anococcygeus muscle but had no effect in the BRP muscle. 2. The inhibition of the NANC response in the rat anococcygeus muscle by pyrogallol was completely reversed by superoxide dismutase suggesting it was due to the generation of superoxide anions. 3. Pyrogallol inhibited the response to nitric oxide (NO) in the rat anococcygeus muscle but not that to 3-isobutyl-1-methyl-xanthine (IBMX) which confirmed a selective action. 4. These results suggest that the NANC neurotransmitter in the rat anococcygeus muscle is susceptible to superoxide anions and may be NO or a substance that can liberate NO.

MeSH Terms
1-Methyl-3-isobutylxanthine/pharmacology Animals Arginine/analogs & derivatives,pharmacology Autonomic Nervous System/physiology Cattle Electric Stimulation Hydroquinones/pharmacology In Vitro Techniques Male Muscle Relaxation/drug effects Muscle, Smooth/drug effects Nitric Oxide/pharmacology Penis/drug effects Pyrogallol/pharmacology Rats Superoxides/metabolism omega-N-Methylarginine
Chemicals
Hydroquinones Pyrogallol Superoxides omega-N-Methylarginine Nitric Oxide Arginine 1-Methyl-3-isobutylxanthine hydroquinone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gillespie J S
Department of Pharmacology, University of Glasgow, Scotland.
Sheng H
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17 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1990.tb14677.x
Published
1990-01-00
Pages
194-6
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1917525
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1990.tb14677.x PMC Full Text View journal details
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