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PMID: 16923387 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The inflammasome: first line of the immune response to cell stress.

Cell ·Vol. 126 ·No. 4 ·2006-08-25 ·Pages 659-62

Ogura Y, Sutterwala FS, Flavell RA

Abstract

The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.

MeSH Terms
Adenosine Triphosphate/metabolism Animals Apoptosis Regulatory Proteins/genetics,metabolism CARD Signaling Adaptor Proteins Calcium Pyrophosphate/metabolism Calcium-Binding Proteins/genetics,metabolism Carrier Proteins/genetics,metabolism Caspase 1/metabolism Cytoskeletal Proteins/genetics,metabolism Enzyme Activation Humans Immune System/physiology Inflammation/metabolism Interleukins/immunology NLR Family, Pyrin Domain-Containing 3 Protein Oxidative Stress Salmonella Infections/immunology Salmonella typhimurium/immunology Uric Acid/metabolism
Chemicals
Apoptosis Regulatory Proteins CARD Signaling Adaptor Proteins Calcium-Binding Proteins Carrier Proteins Cytoskeletal Proteins Interleukins Ipaf protein, mouse NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 protein, human Pycard protein, mouse Uric Acid Adenosine Triphosphate Caspase 1 Calcium Pyrophosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ogura Yasunori
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Sutterwala Fayyaz S
Flavell Richard A
Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/j.cell.2006.08.002
Published
2006-08-25
Pages
659-62
Language
English
Region
United States
NLM ID
0413066
Subset
IM
Grants
NIDDK NIH HHS · DK066338-03 · United States
NIAID NIH HHS · T32 AI-007517 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2006.08.002 View journal details
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