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PMID: 16930455 Published · epublish English Journal Article

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.

Molecular neurodegeneration ·Vol. 1 ·2006-08-18 ·Pages 8

Cam JA, Bu G

Abstract

Amyloid-beta peptide (Abeta) accumulation in the brain is an early, toxic event in the pathogenesis of Alzheimer's disease (AD). Abeta is produced by proteolytic processing of a transmembrane protein, beta-amyloid precursor protein (APP), by beta- and gamma-secretases. Mounting evidence has demonstrated that alterations in APP cellular trafficking and localization directly impact its processing to Abeta. Recent studies have shown that members of the low-density lipoprotein receptor family, including LRP, LRP1B, SorLA/LR11, and apolipoprotein E (apoE) receptor 2, interact with APP and regulate its endocytic trafficking. Another common feature of these receptors is their ability to bind apoE, which exists in three isoforms in humans and the presence of the epsilon4 allele represents a genetic risk factor for AD. In this review, we summarize the current understanding of the function of these apoE receptors with a focus on their role in APP trafficking and processing. Knowledge of the interactions between these distinct low-density lipoprotein receptor family members and APP may ultimately influence future therapies for AD.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cam Judy A
Department of Pediatrics, Washington University School of Medicine, St, Louis, Missouri 63110, USA. [email protected]
Bu Guojun
References (110)
110 references, click to expand
  1. Activation and functional characterization of the mosaic receptor SorLA/LR11.
    J Biol Chem. 2001 Jun 22;276(25):22788-96 PMID: 11294867
  2. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.
    Cell. 1992 Oct 30;71(3):411-21 PMID: 1423604
  3. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands.
    Biochemistry. 2003 Nov 11;42(44):13049-57 PMID: 14596620
  4. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
    J Biol Chem. 2004 Jul 9;279(28):29639-46 PMID: 15126508
  5. The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.
    Neurosci Lett. 1999 Jan 4;259(1):29-32 PMID: 10027548
  6. Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor.
    J Biol Chem. 2006 Feb 10;281(6):3425-31 PMID: 16332682
  7. Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.
    Lab Invest. 2002 May;82(5):639-43 PMID: 12004004
  8. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory.
    Prog Neurobiol. 2003 May;70(1):1-32 PMID: 12927332
  9. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
    J Clin Invest. 2002 Nov;110(10):1375-81 PMID: 12438432
  10. Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.
    Neurology. 1998 Jun;50(6):1905-7 PMID: 9633759
  11. Association at LRP gene locus with sporadic late-onset Alzheimer's disease.
    Lancet. 1998 Jun 13;351(9118):1787-8 PMID: 9635959
  12. LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.
    Brain Res Mol Brain Res. 2002 Jul 15;104(1):38-46 PMID: 12117549
  13. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Biochemistry. 1999 Jul 27;38(30):9728-34 PMID: 10423252
  14. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.
    Mol Cell Biol. 2004 Oct;24(20):8872-83 PMID: 15456862
  15. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
    Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81 PMID: 8446617
  16. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals.
    J Neurochem. 2003 Mar;84(6):1442-51 PMID: 12614344
  17. Loss of apolipoprotein E receptor LR11 in Alzheimer disease.
    Arch Neurol. 2004 Aug;61(8):1200-5 PMID: 15313836
  18. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing.
    EMBO J. 2002 Nov 1;21(21):5691-700 PMID: 12411487
  19. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
    Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5 PMID: 16344478
  20. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
    Mol Cell Biol. 1996 Nov;16(11):6229-41 PMID: 8887653
  21. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.
    J Biol Chem. 1995 Dec 29;270(52):30853-6 PMID: 8537337
  22. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
    J Biol Chem. 1999 Dec 17;274(51):36801-7 PMID: 10593990
  23. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.
    J Biol Chem. 1998 Dec 11;273(50):33556-60 PMID: 9837937
  24. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.
    J Biol Chem. 2002 Oct 18;277(42):39944-52 PMID: 12167620
  25. Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.
    J Biol Chem. 1993 Jan 5;268(1):608-12 PMID: 8416966
  26. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein.
    J Biol Chem. 2000 Jun 2;275(22):17187-94 PMID: 10747918
  27. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.
    EMBO J. 2004 Oct 13;23(20):4106-15 PMID: 15385965
  28. Recognition of alpha 2-macroglobulin by the low density lipoprotein receptor-related protein requires the cooperation of two ligand binding cluster regions.
    J Biol Chem. 2001 Oct 19;276(42):39484-91 PMID: 11507091
  29. Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation.
    J Neurochem. 2005 Dec;95(6):1677-88 PMID: 16236032
  30. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
    J Biol Chem. 2005 May 6;280(18):17777-85 PMID: 15749709
  31. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.
    Neuron. 2004 Aug 5;43(3):333-44 PMID: 15294142
  32. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.
    J Clin Invest. 2000 Nov;106(9):1159-66 PMID: 11067868
  33. Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.
    FEBS Lett. 1990 Dec 10;276(1-2):151-5 PMID: 1702392
  34. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
    Biochemistry. 2006 Feb 28;45(8):2618-28 PMID: 16489755
  35. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
    J Biol Chem. 2005 Jul 22;280(29):27303-9 PMID: 15917251
  36. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.
    J Cell Biol. 2003 Jan 6;160(1):113-23 PMID: 12515826
  37. Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein.
    J Cell Sci. 2001 Mar;114(Pt 5):899-908 PMID: 11181173
  38. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.
    J Neurosci. 2000 Jan 15;20(2):542-9 PMID: 10632583
  39. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.
    Neuron. 2005 Aug 18;47(4):567-79 PMID: 16102539
  40. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
    Biochem Biophys Res Commun. 1984 May 16;120(3):885-90 PMID: 6375662
  41. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates.
    J Biol Chem. 2001 May 25;276(21):18000-6 PMID: 11279214
  42. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
    Nature. 1989 Sep 14;341(6238):144-7 PMID: 2506449
  43. Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.
    J Biol Chem. 1994 Jun 3;269(22):15827-32 PMID: 7515061
  44. Evidence that production and release of amyloid beta-protein involves the endocytic pathway.
    J Biol Chem. 1994 Jul 1;269(26):17386-9 PMID: 8021238
  45. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
    J Neurosci. 2006 Jan 11;26(2):418-28 PMID: 16407538
  46. Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms.
    Genomics. 1998 Sep 1;52(2):138-44 PMID: 9782078
  47. Alzheimer's risk associated with human apolipoprotein E, alpha-2 macroglobulin and lipoprotein receptor related protein polymorphisms: absence of genetic interactions, and modulation by gender.
    Neurosci Lett. 2000 Aug 11;289(3):213-6 PMID: 10961667
  48. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
    J Biol Chem. 2003 Jul 18;278(29):26687-94 PMID: 12736250
  49. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
    J Neurosci. 2000 Nov 1;20(21):7951-63 PMID: 11050115
  50. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
    J Biol Chem. 1992 Jan 5;267(1):546-54 PMID: 1730616
  51. Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.
    J Biol Chem. 2005 Apr 15;280(15):15464-70 PMID: 15705569
  52. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
    Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6 PMID: 16174740
  53. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.
    J Biol Chem. 1996 Dec 6;271(49):31379-83 PMID: 8940146
  54. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
    Nature. 1991 Feb 21;349(6311):704-6 PMID: 1671712
  55. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
    Science. 2001 Jul 6;293(5527):115-20 PMID: 11441186
  56. Chylomicron assembly and catabolism: role of apolipoproteins and receptors.
    Biochim Biophys Acta. 1996 May 20;1300(3):151-70 PMID: 8679680
  57. Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis.
    J Neurochem. 2000 Mar;74(3):1131-9 PMID: 10693945
  58. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties.
    J Biol Chem. 1999 Oct 29;274(44):31305-11 PMID: 10531329
  59. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).
    Brain Res. 1996 Nov 18;740(1-2):6-14 PMID: 8973792
  60. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
    Science. 1990 Oct 12;250(4978):279-82 PMID: 2218531
  61. Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member.
    J Biol Chem. 1996 Oct 4;271(40):24761-8 PMID: 8798746
  62. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
    Mol Cell Biol. 2004 May;24(9):3782-93 PMID: 15082773
  63. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.
    Ann Neurol. 1995 Feb;37(2):211-7 PMID: 7531418
  64. Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.
    Neurosci Lett. 1998 Mar 13;244(2):65-8 PMID: 9572586
  65. Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.
    Brain Res Mol Brain Res. 2001 Mar 5;87(2):238-45 PMID: 11245926
  66. The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family.
    Int Rev Cytol. 2001;209:79-116 PMID: 11580203
  67. Regulation of ApoE receptor proteolysis by ligand binding.
    Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):31-9 PMID: 15950758
  68. Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain.
    Biochem Biophys Res Commun. 1990 Feb 14;166(3):1192-200 PMID: 1689572
  69. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
    J Biol Chem. 2000 Mar 10;275(10):7410-5 PMID: 10702315
  70. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Science. 1999 Oct 22;286(5440):735-41 PMID: 10531052
  71. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
    J Biol Chem. 1990 Feb 25;265(6):3116-23 PMID: 1968060
  72. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
    Cancer Res. 2004 Jun 1;64(11):3741-7 PMID: 15172977
  73. Two apolipoprotein E mimetic peptides, ApoE(130-149) and ApoE(141-155)2, bind to LRP1.
    Biochemistry. 2004 Jun 15;43(23):7328-35 PMID: 15182176
  74. Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths.
    Biophys J. 1994 Sep;67(3):1216-28 PMID: 7811936
  75. Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes.
    Brain Res Mol Brain Res. 1997 Jul;47(1-2):147-56 PMID: 9221912
  76. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease.
    Neurology. 1997 Jul;49(1):56-61 PMID: 9222170
  77. Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.
    J Neurochem. 1999 Oct;73(4):1393-8 PMID: 10501182
  78. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain.
    J Biol Chem. 1995 Feb 24;270(8):3565-73 PMID: 7876092
  79. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.
    J Neurochem. 1997 Nov;69(5):1904-11 PMID: 9349534
  80. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
    EMBO J. 1988 Dec 20;7(13):4119-27 PMID: 3266596
  81. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.
    Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11551-6 PMID: 11016955
  82. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.
    Neurogenetics. 1998 Mar;1(3):179-83 PMID: 10737120
  83. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.
    J Neurosci Res. 2002 Sep 1;69(5):567-77 PMID: 12210822
  84. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro.
    J Neuropathol Exp Neurol. 2001 May;60(5):430-40 PMID: 11379818
  85. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.
    Biochemistry. 1993 May 11;32(18):4693-7 PMID: 8490014
  86. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
    Nature. 1987 Feb 19-25;325(6106):733-6 PMID: 2881207
  87. Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.
    Neurosci Lett. 1997 May 9;227(1):68-70 PMID: 9178861
  88. SorLA signaling by regulated intramembrane proteolysis.
    J Biol Chem. 2006 May 26;281(21):14547-53 PMID: 16531402
  89. Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator.
    J Cell Sci. 2000 Dec;113 Pt 24:4475-85 PMID: 11082041
  90. F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein.
    Mol Cell Biol. 2005 Nov;25(21):9259-68 PMID: 16227578
  91. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.
    J Neurosci. 2001 Nov 1;21(21):8354-61 PMID: 11606623
  92. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein.
    Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1075-80 PMID: 14732699
  93. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
    J Biol Chem. 2000 Aug 18;275(33):25616-24 PMID: 10827173
  94. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines.
    Cancer Res. 2000 Apr 1;60(7):1961-7 PMID: 10766186
  95. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
    Neuron. 1994 Jul;13(1):45-53 PMID: 8043280
  96. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.
    J Biol Chem. 2002 May 24;277(21):18736-43 PMID: 11907044
  97. Mice deficient for the amyloid precursor protein gene.
    Ann N Y Acad Sci. 1996 Jan 17;777:421-6 PMID: 8624124
  98. Strategies for disease modification in Alzheimer's disease.
    Nat Rev Neurosci. 2004 Sep;5(9):677-85 PMID: 15322526
  99. Molecular mapping of Alzheimer-type dementia in Down's syndrome.
    Ann Neurol. 1998 Mar;43(3):380-3 PMID: 9506555
  100. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.
    J Biol Chem. 2001 Aug 3;276(31):28889-96 PMID: 11384978
  101. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.
    Physiol Rev. 1997 Oct;77(4):1081-132 PMID: 9354812
  102. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein.
    Science. 1990 Jun 1;248(4959):1126-8 PMID: 2111585
  103. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
    J Biol Chem. 1999 Jul 2;274(27):18851-6 PMID: 10383380
  104. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
    Neuron. 2005 Jul 21;47(2):191-9 PMID: 16039562
  105. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.
    J Cell Sci. 1996 May;109 ( Pt 5):991-8 PMID: 8743946
  106. Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese.
    Neurosci Lett. 1998 May 8;247(1):33-6 PMID: 9637403
  107. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.
    J Neurosci. 2006 Feb 1;26(5):1596-603 PMID: 16452683
  108. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.
    J Biol Chem. 2002 Nov 1;277(44):42366-71 PMID: 12194987
  109. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
    Cell. 1999 Jun 11;97(6):689-701 PMID: 10380922
  110. Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.
    Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2548-53 PMID: 14983046
Article Info
Journal
Molecular neurodegeneration
Abbr.
Mol Neurodegener
ISSN
1750-1326
DOI
10.1186/1750-1326-1-8
Email
[email protected]
Published
2006-08-18
Epub
2006-00-18
Pages
8
Language
English
Region
England
NLM ID
101266600
PMCID
PMC1563464
External Links
PubMed source DOI: 10.1186/1750-1326-1-8 PMC Full Text View journal details
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