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PMID: 1696684 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.

Nature ·Vol. 346 ·No. 6285 ·1990-08-16 ·Pages 629-33

Pircher H, Moskophidis D, Rohrer U, Bürki K, Hengartner H, Zinkernagel RM

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

MeSH Terms

Amino Acid Sequence Animals Antigens, Viral/genetics,immunology Base Sequence Cloning, Molecular Epitopes/genetics,immunology Genetic Variation Glycoproteins/genetics Lymphocytic Choriomeningitis/immunology,microbiology Lymphocytic choriomeningitis virus/genetics,immunology Mice Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Mutation Polymerase Chain Reaction Receptors, Antigen, T-Cell/genetics,immunology Spleen/microbiology T-Lymphocytes, Cytotoxic/immunology

Chemicals

Antigens, Viral Epitopes Glycoproteins Receptors, Antigen, T-Cell

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Pircher H

Institute of Pathology, University Hospital, Zurich, Switzerland.

Moskophidis D

Rohrer U

Bürki K

Hengartner H

Zinkernagel R M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/346629a0

Published

1990-08-16

Pages

629-33

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/346629a0 View journal details

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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.

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