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PMID: 17010565 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells.

Genomics ·Vol. 89 ·No. 1 ·2007-01-00 ·Pages 1-9

Yi JM, Schuebel K, Kim HS

Abstract

Human endogenous retroviral sequences family P (HERV-P) proviral sequences have been located within the human genome. Here, we identify and analyze novel putative structural genes of HERV-P in primates, human tissues, and cancer cells with an aim toward better understanding their evolutionary relationships and transcriptional potential. The expression pattern of HERV-P structural genes indicates that they are actively amplified in human tissues and widely expressed in cancer cells, suggesting a potential role in carcinogenesis. Phylogenetic analyses suggest that the HERV-P family may be divided into two distinct categories that arose during primate evolution via active gene duplication. Taken together, our data provide a better understanding of the dynamic evolutionary features and potential functional roles of the HERV-P gene family.

MeSH Terms

Animals Base Sequence Cell Line, Tumor Cloning, Molecular DNA Primers/genetics Endogenous Retroviruses/classification,genetics,isolation & purification Evolution, Molecular Gene Expression Profiling Genes, Viral Humans Molecular Biology Molecular Sequence Data Neoplasms/genetics,virology Phylogeny Primates/genetics,virology Sequence Analysis, DNA

Chemicals

DNA Primers

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Yi Joo-Mi

Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.

Schuebel Kornel

Kim Heui-Soo

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1016/j.ygeno.2006.08.010

Published

2007-01-00

Epub

2006-00-27

Pages

1-9

Language

English

Region

United States

NLM ID

8800135

Subset

Databases

GENBANK

AB239191, AB239192, AB239193, AB239194, AB239195, AB239196, AB239197, AB239198, AB239199, AB239200, AB239201, AB239202, AB239203, AB239204, AB239205, AB239206, AB239207, AB239208, AB239209, AB239210, AB239211, AB239212, AB239213, AB239214, AB239215, AB239216, AB239217, AB239218, AB239219, AB239220, AB239221, AB239222, AB239223, AB239224, AB239225, AB239226, AB239227, AB239228, AB239229, AB239230, AB239231, AB239232, AB239233, AB239234, AB239235, AB239236, AB239237, AB239238, AB239239, AB239240, AB239241, AB239242, AB239243, AB239244, AB239245, AB239246, AB239247, AB239248, AB239999, AB240000, AB240001, AB240002, AB240003, AB240004, AB240005, AB240006, AB240007, AB240008, AB240009, AB240010, AB240011, AB240012, AB240013, AB240014, AB240015, AB240016, AB240017, AB240018, AB240019, AB240020, AB240021, AB240022, AB240023, AB240024, AB240025, AB240026, AB240027, AB240028, AB240029, AB240030, AB240031, AB240032, AB240033, AB240034, AB240035, AB240036, AB240037, AB240038, AB240039, AB240040, AB240041, AB240042, AB240043, AB240044, AB240045

External Links

PubMed source DOI: 10.1016/j.ygeno.2006.08.010 View journal details

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Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells.

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