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PMID: 17036339 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

In vivo measurement of plaque burden in a mouse model of Alzheimer's disease.

Journal of magnetic resonance imaging : JMRI ·Vol. 24 ·No. 5 ·2006-11-00 ·Pages 1011-7

Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R

Abstract

To demonstrate an MRI method for directly visualizing amyloid-beta (Abeta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T1rho relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain. We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpresses human amyloid precursor protein, and measured T1rho via quantitative relaxometric maps. A significant decrease in T1rho was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T1rho and the age of the animals. T1rho relaxometry may be a sensitive method for noninvasively determining AD-related pathology in APP/PS1 mice.

MeSH Terms
Alzheimer Disease/pathology Animals Disease Models, Animal Image Interpretation, Computer-Assisted/methods Magnetic Resonance Imaging/methods Mice Mice, Transgenic Plaque, Amyloid/pathology Severity of Illness Index
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Borthakur Arijitt
Metabolic Magnetic Resonance Research & Computing Center (MMRRCC), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6100, USA. [email protected]
Gur Tamar
Wheaton Andrew J
Corbo Matthew
Trojanowski John Q
Lee Virginia M-Y
Reddy Ravinder
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Article Info
Journal
Journal of magnetic resonance imaging : JMRI
Abbr.
J Magn Reson Imaging
ISSN
1053-1807
DOI
10.1002/jmri.20751
Email
[email protected]
Published
2006-11-00
Pages
1011-7
Language
English
Region
United States
NLM ID
9105850
PMCID
PMC2859034
Subset
IM
Grants
NCRR NIH HHS · P41 RR002305-246021 · United States
NCRR NIH HHS · RR02305 · United States
NCRR NIH HHS · P41 RR002305-236875 · United States
NCRR NIH HHS · P41 RR002305-255549 · United States
NCRR NIH HHS · P41 RR002305 · United States
External Links
PubMed source DOI: 10.1002/jmri.20751 PMC Full Text View journal details
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