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PMID: 1704192 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing.

The American journal of pathology ·Vol. 138 ·No. 2 ·1991-02-00 ·Pages 427-40

Chuong CM, Chen HM

Abstract

Both neural cell adhesion molecules (N-CAM) and tenascin (cytotactin) are important in embryonic morphogenesis but their expression is reduced greatly in adults. This study examined whether they are induced during wound healing. The spatial and temporal expression patterns of these two and other adhesion molecules in the healing of skin, cartilage, and tendon were compared. Neural cell adhesion molecules, tenascin, and fibronectin are induced in the granulation tissue but the order of prevalence is fibronectin, tenascin, N-CAM. The order of appearance is N-CAM and fibronectin, and then tenascin. The order of disappearance is N-CAM, tenascin, fibronectin. Liver cell adhesion molecules are present in the epidermis undergoing re-epithelization. Explant cultures showed that N-CAM and tenascin are synthesized by wound fibroblasts. These results suggest that N-CAM and tenascin, widely used in embryonic morphogenesis, are induced in a variety of connective tissues during wound healing.

MeSH Terms
Animals Cell Adhesion Cell Adhesion Molecules/metabolism Cell Adhesion Molecules, Neuronal/metabolism Chickens Connective Tissue/injuries,physiology Culture Techniques Extracellular Matrix Proteins/metabolism Fibronectins/metabolism Liver/injuries,physiology Mice Mice, Inbred Strains Skin/injuries,metabolism Stomach/injuries,physiology Sutures Tenascin Wound Healing/physiology
Chemicals
Cell Adhesion Molecules Cell Adhesion Molecules, Neuronal Extracellular Matrix Proteins Fibronectins Tenascin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chuong C M
Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033.
Chen H M
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1991-02-00
Pages
427-40
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886190
Subset
IM
Grants
NICHD NIH HHS · HD 24301 · United States
External Links
PubMed source PMC Full Text View journal details
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