Triple post-transcriptional control.

Molecular microbiology ·Vol. 4 ·No. 9 ·1990-09-00 ·Pages 1419-23

Bechhofer DH

Abstract

The ermC gene confers resistance to MLS antibiotics in a Bacillus subtilis host. Synthesis of the ermC gene product, a ribosomal RNA methylase, is inducible by the addition of subinhibitory concentrations of erythromycin. Regulation of ermC gene expression occurs at the post-transcriptional level in three ways: translational attenuation, translational autoregulation, and messenger RNA stabilization.

Related Genes

ermC

MeSH Terms

Bacillus subtilis/drug effects,genetics Base Sequence Drug Resistance, Microbial/genetics Erythromycin/pharmacology Gene Expression Regulation, Bacterial Genes, Bacterial Methyltransferases/genetics Molecular Sequence Data Nucleic Acid Conformation Protein Biosynthesis RNA, Bacterial/genetics RNA, Messenger/genetics Transcription, Genetic

Chemicals

RNA, Bacterial RNA, Messenger Erythromycin Methyltransferases rRNA (adenosine-O-2'-)methyltransferase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bechhofer D H

Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029.

Article Info

Journal

Molecular microbiology

Abbr.

Mol Microbiol

ISSN

0950-382X

DOI

10.1111/j.1365-2958.1990.tb02051.x

Published

1990-09-00

Pages

1419-23

Language

English

Region

England

NLM ID

8712028

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2958.1990.tb02051.x View journal details

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