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PMID: 17055429 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The regulation of INK4/ARF in cancer and aging.

Cell ·Vol. 127 ·No. 2 ·2006-10-20 ·Pages 265-75

Kim WY, Sharpless NE

Abstract

Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.

MeSH Terms

ADP-Ribosylation Factors/genetics,metabolism Aging/metabolism Animals Cell Transformation, Neoplastic/metabolism Cellular Senescence Cyclin-Dependent Kinase Inhibitor Proteins/genetics,metabolism Cyclin-Dependent Kinase Inhibitor p15/metabolism Cyclin-Dependent Kinase Inhibitor p16/metabolism Gene Expression Regulation, Neoplastic Gene Silencing Humans

Chemicals

Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16 ADP-Ribosylation Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kim William Y

Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA.

Sharpless Norman E

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2006.10.003

Published

2006-10-20

Pages

265-75

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/j.cell.2006.10.003 View journal details

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The regulation of INK4/ARF in cancer and aging.

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