Home LiteratureArticle Details

PMID: 17056646 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96.

Molecular biology and evolution ·Vol. 24 ·No. 1 ·2007-01-00 ·Pages 306-14

Presgraves DC, Stephan W

Abstract

Nup96 is involved in a lethal hybrid incompatibility between 2 fruit fly species, Drosophila melanogaster and Drosophila simulans. Recurrent adaptive evolution drove the rapid functional divergence of Nup96 in both the D. melanogaster and the D. simulans lineages. Functional divergence of Nup96 between these 2 species is unexpected as Nup96 encodes part of the Nup107 subcomplex, an architectural component of nuclear pore complexes, the macromolecular channels in nuclear envelopes that mediate nucleocytoplasmic traffic in all eukaryotes. Here we study the evolutionary histories of 5 of Nup96's protein interactors--3 stable Nup107 subcomplex proteins (Nup75, Nup107, and Nup133) and 2 mobile nucleoporins (Nup98 and Nup153)--and show that all 5 have experienced recurrent adaptive evolution. These results are consistent with selection-driven coevolution among molecular interactors within species causing the incidental evolution of incompatible interactions seen in hybrids between species. We suggest that genetic conflict-driven processes may have contributed to the rapid molecular evolution of Nup107 subcomplex genes.

MeSH Terms

Animals Drosophila/chemistry,genetics,metabolism Drosophila Proteins/genetics,metabolism Drosophila melanogaster/genetics Evolution, Molecular Molecular Sequence Data Multiprotein Complexes Nuclear Pore Complex Proteins/genetics,metabolism

Chemicals

Drosophila Proteins Multiprotein Complexes Nuclear Pore Complex Proteins nuclear pore complex protein 96

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Presgraves Daven C

Section of Evolutionary Biology, Biocenter, University of Munich, Planegg-Martinsried, Germany. [email protected]

Stephan Wolfgang

Article Info

Journal

Molecular biology and evolution

Abbr.

Mol Biol Evol

ISSN

0737-4038

DOI

10.1093/molbev/msl157

[email protected]

Published

2007-01-00

Epub

2006-00-20

Pages

306-14

Language

English

Region

United States

NLM ID

8501455

Subset

Databases

GENBANK

EF057923, EF057924, EF057925, EF057926, EF057927, EF057928, EF057929, EF057930, EF057931, EF057932, EF057933, EF057934, EF057935, EF057936, EF057937, EF057938, EF057939, EF057940, EF057941, EF057942, EF057943, EF057944, EF057945, EF057946, EF057947, EF057948, EF057949, EF057950, EF057951, EF057952, EF057953, EF057954, EF057955, EF057956, EF057957, EF057958, EF057959, EF057960, EF057961, EF057962, EF057963, EF057964, EF057965, EF057966, EF057967, EF057968, EF057969, EF057970, EF057971, EF057972, EF057973, EF057974, EF057975, EF057976, EF057977, EF057978, EF057979, EF057980, EF057981, EF057982, EF057983, EF057984, EF057985, EF057986, EF057987, EF057988, EF057989, EF057990, EF057991, EF057992, EF057993, EF057994, EF057995, EF057996, EF057997, EF057998, EF057999, EF058000, EF058001, EF058002, EF058003, EF058004, EF058005, EF058006, EF058007, EF058008, EF058009, EF058010, EF058011, EF058012, EF058013, EF058014, EF058015, EF058016, EF058017, EF058018, EF058019, EF058020, EF058021, EF058022, EF058023, EF058024, EF058025, EF058026, EF058027, EF058028, EF058029, EF058030, EF058031, EF058032, EF058033, EF058034, EF058035, EF058036, EF058037, EF058038, EF058039, EF058040, EF058041, EF058042, EF058043, EF058044, EF058045

External Links

PubMed source DOI: 10.1093/molbev/msl157 View journal details

Analysis Services

Pervasive adaptive evolution among interactors of the Drosophila hybrid inviability gene, Nup96.

Contact

WeChat Official Account