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PMID: 17057751 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Collecting and organizing systematic sets of protein data.

Nature reviews. Molecular cell biology ·Vol. 7 ·No. 11 ·2006-11-00 ·Pages 803-12

Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S

Abstract

Systems biology, particularly of mammalian cells, is data starved. However, technologies are now in place to obtain rich data, in a form suitable for model construction and validation, that describes the activities, states and locations of cell-signalling molecules. The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data.

MeSH Terms
Animals Cluster Analysis Computational Biology/methods,statistics & numerical data Databases, Protein Gene Expression Regulation Humans Immunoassay Models, Biological Protein Processing, Post-Translational
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Albeck John G
Center for Cell Decision Processes, Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
MacBeath Gavin
White Forest M
Sorger Peter K
Lauffenburger Douglas A
Gaudet Suzanne
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
Published
2006-11-00
Pages
803-12
Language
English
Region
England
NLM ID
100962782
Subset
IM
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