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PMID: 17060589 Published · ppublish English Case Reports Journal Article Research Support, N.I.H., Extramural

Parkinsonism, Lrrk2 G2019S, and tau neuropathology.

Neurology ·Vol. 67 ·No. 8 ·2006-10-24 ·Pages 1506-8

Rajput A, Dickson DW, Robinson CA, Ross OA, Dächsel JC, Lincoln SJ, Cobb SA, Rajput ML, Farrer MJ

Abstract

Lrrk2 G2019S is predominantly associated with alpha-synuclein-immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus alpha-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or alpha-synuclein protein with Lrrk2.

MeSH Terms

Aged Brain/metabolism,pathology Cell Line Disability Evaluation Disease Progression Female Glycine Humans Immunohistochemistry Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Middle Aged Mutation Neurofibrillary Tangles/metabolism,pathology Parkinsonian Disorders/genetics,pathology,physiopathology Pedigree Protein Serine-Threonine Kinases/genetics Serine alpha-Synuclein/metabolism tau Proteins/metabolism

Chemicals

alpha-Synuclein tau Proteins Serine LRRK2 protein, human Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases Glycine

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Rajput A

Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.

Dickson D W

Robinson C A

Ross O A

Dächsel J C

Lincoln S J

Cobb S A

Rajput M L

Farrer M J

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

1526-632X

DOI

10.1212/01.wnl.0000240220.33950.0c

Published

2006-10-24

Pages

1506-8

Language

English

Region

United States

NLM ID

0401060

Subset

Grants

NIA NIH HHS · P01 AG17216 · United States

NINDS NIH HHS · P50 NS40256 · United States

NIEHS NIH HHS · R01 ES013941 · United States

External Links

PubMed source DOI: 10.1212/01.wnl.0000240220.33950.0c View journal details

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Parkinsonism, Lrrk2 G2019S, and tau neuropathology.

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