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PMID: 170606 Published · ppublish English Journal Article

Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 7 ·1975-07-00 ·Pages 2563-7

Khoury G, Howley PM, Garon C, Mullarkey MF, Takemoto KK, Martin MA

Abstract

A number of hybridization techniques have been used to assess the homology between the genomes of BK virus (BKV) and simian virus 40 (SV40). A noncontiguous set of homologous sequences has been localized primarily within the late region of the SV40 genome, and these sequences presumably account for the cross-reaction between V-antigens of the two viruses. The reason for the relatively strong crossreaction between SV40 and BKV T-antigens is still unclear. The sequence homology and similarity in genomic organization suggest a close relationship between these papovaviruses.

MeSH Terms
BK Virus/analysis Base Sequence DNA Restriction Enzymes DNA, Viral Deoxyribonucleotides/analysis Genes Haemophilus influenzae/enzymology Microscopy, Electron Nucleic Acid Hybridization Papillomaviridae/analysis Polyomaviridae Polyomavirus/analysis Simian virus 40/analysis Species Specificity
Chemicals
DNA, Viral Deoxyribonucleotides DNA Restriction Enzymes
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Khoury G
Howley P M
Garon C
Mullarkey M F
Takemoto K K
Martin M A
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.7.2563
Published
1975-07-00
Pages
2563-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432809
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.7.2563 PMC Full Text View journal details
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