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PMID: 17064417 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT.

Genome biology ·Vol. 7 ·No. 10 ·2006-00-00 ·Pages R97

Cheung TH, Kwan YL, Hamady M, Liu X

Abstract

Deciphering gene regulatory networks requires the systematic identification of functional cis-acting regulatory elements. We present a suite of web-based bioinformatics tools, called GeneACT http://promoter.colorado.edu, that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3'-untranslated regions that are conserved across multiple mammalian species.

MeSH Terms
Animals Genome Genome, Human Humans Mice Rats Regulatory Sequences, Nucleic Acid Transcription, Genetic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cheung Tom Hiu
Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, Colorado 80309, USA.
Kwan Yin Lam
Hamady Micah
Liu Xuedong
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
DOI
10.1186/gb-2006-7-10-r97
Published
2006-00-00
Epub
2006-00-25
Pages
R97
Language
English
Region
England
NLM ID
100960660
PMCID
PMC1794569
Subset
IM
Grants
NHLBI NIH HHS · 5T32HL07851 · United States
NIGMS NIH HHS · T32 GM008759 · United States
NCI NIH HHS · CA095527 · United States
NCI NIH HHS · R01 CA095527 · United States
NHLBI NIH HHS · T32 HL007851 · United States
External Links
PubMed source DOI: 10.1186/gb-2006-7-10-r97 PMC Full Text View journal details
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