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PMID: 1706525 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regional differences in calcium-release channels from heart.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 6 ·1991-03-15 ·Pages 2486-9

Borgatta L, Watras J, Katz AM, Ehrlich BE

Abstract

The heart is a heterogeneous tissue composed of several cell types tailored for specialized functions. We found that intracellular channels also exhibit regional specialization. In cardiac and skeletal muscle these channels are called the calcium-release channel and are identified by activation with either calcium or caffeine and inhibition by the hexavalent cation ruthenium red. The calcium-release channel of the sarcoplasmic reticulum from the interventricular septum has a smaller conductance (31 pS vs. 100 pS) and has longer open and closed times when compared with the channel from left-ventricular free wall. An additional calcium-permeable channel with an even smaller conductance (17 pS) was found in the septum, and this channel is similar to the inositol 1,4,5-trisphosphate-gated channel from smooth muscle and different from the calcium-release channel (ryanodine receptor) from skeletal and cardiac muscle. The inositol 1,4,5-trisphosphate-activated channel may be derived from specialized conducting tissue that is relatively abundant in the septum, whereas the other calcium-release channels may be derived from regionally specialized myocardial cells in the septum and free wall.

MeSH Terms
Animals Caffeine/pharmacology Calcium/pharmacology Calcium Channels/drug effects,physiology Dogs Heart/physiology Kinetics Lipid Bilayers Ruthenium Red/pharmacology Sarcoplasmic Reticulum/physiology Ventricular Function
Chemicals
Calcium Channels Lipid Bilayers Ruthenium Red Caffeine Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Borgatta L
Department of Medicine, University of Connecticut, Farmington 06030.
Watras J
Katz A M
Ehrlich B E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.6.2486
Published
1991-03-15
Pages
2486-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51257
Subset
IM
Grants
NIGMS NIH HHS · GMS-39029 · United States
NHLBI NIH HHS · HL-33026 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.6.2486 PMC Full Text View journal details
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