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PMID: 17067771 Published · ppublish English Journal Article Review

Hormesis and aging in Caenorhabditis elegans.

Experimental gerontology ·Vol. 41 ·No. 10 ·2006-10-00 ·Pages 935-9

Cypser JR, Tedesco P, Johnson TE

Abstract

Hormesis has emerged as an important manipulation for the study of aging. Although hormesis is manifested in manifold combinations of stress and model organism, the mechanisms of hormesis are only partly understood. The increased stress resistance and extended survival caused by hormesis can be manipulated to further our understanding of the roles of intrinsic and induced stress resistance in aging. Genes of the dauer/insulin/insulin-like signaling (IIS) pathway have well-established roles in aging in Caenorhabditis elegans. Here, we discuss the role of some of those genes in the induced stress resistance and induced life extension attributable to hormesis. Mutations in three genes (daf-16, daf-18, and daf-12) block hormetically induced life extension. However, of these three, only daf-18 appears to be required for a full induction of thermotolerance induced by hormesis, illustrating possible separation of the genetic requirements for stress resistance and life extension. Mutations in three other genes of this pathway (daf-3, daf-5, and age-1) do not block induced life extension or induced thermotolerance; daf-5 mutants may be unusually sensitive to hormetic conditions.

MeSH Terms
Aging/genetics Animals Caenorhabditis elegans/genetics Caenorhabditis elegans Proteins/genetics Caloric Restriction Forkhead Transcription Factors Genes, Helminth/genetics Hot Temperature Insulin/genetics Insulin-Like Growth Factor II/genetics Longevity/genetics Mutation Receptors, Cytoplasmic and Nuclear/genetics Signal Transduction/genetics Stress, Physiological/physiopathology Transcription Factors/genetics
Chemicals
Caenorhabditis elegans Proteins DAF-12 protein, C elegans DAF-18 protein, C elegans Forkhead Transcription Factors Insulin Receptors, Cytoplasmic and Nuclear Transcription Factors daf-16 protein, C elegans Insulin-Like Growth Factor II
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cypser James R
University of Colorado, Institute for Behavioral Genetics, Box 447 Boulder, CO 80309, Fedex, 1480 30th St., Boulder, CO 80303, USA. [email protected]
Tedesco Pat
Johnson Thomas E
References (53)
53 references, click to expand
  1. Longevity hormesis. A review.
    Mech Ageing Dev. 1990 Jan;51(1):1-31 PMID: 2405215
  2. Aging affects expression of 70-kDa heat shock proteins in Drosophila.
    J Biol Chem. 1991 May 15;266(14):9332-8 PMID: 1902836
  3. Production of sperm reduces nematode lifespan.
    Nature. 1992 Dec 3;360(6403):456-8 PMID: 1448167
  4. Oxidative stress and ageing in Caenorhabditis elegans.
    Biochem J. 1993 Jun 1;292 ( Pt 2):605-8 PMID: 8389142
  5. Aging and resistance to oxidative damage in Caenorhabditis elegans.
    Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8905-9 PMID: 8415630
  6. A C. elegans mutant that lives twice as long as wild type.
    Nature. 1993 Dec 2;366(6454):461-4 PMID: 8247153
  7. Thermotolerance of a long-lived mutant of Caenorhabditis elegans.
    J Gerontol. 1994 Nov;49(6):B270-6 PMID: 7963273
  8. Chronic caloric restriction induces stress proteins in the hypothalamus of rats.
    Mech Ageing Dev. 1994 Oct 1;76(1):11-23 PMID: 7845058
  9. Genes that regulate both development and longevity in Caenorhabditis elegans.
    Genetics. 1995 Apr;139(4):1567-83 PMID: 7789761
  10. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.
    Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7540-4 PMID: 7638227
  11. Dietary restriction.
    Exp Gerontol. 1995 May-Aug;30(3-4):291-8 PMID: 7556508
  12. Caloric restriction and aging.
    Sci Am. 1996 Jan;274(1):46-52 PMID: 8533065
  13. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
    Genetics. 1995 Dec;141(4):1399-406 PMID: 8601482
  14. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.
    Genetics. 1988 Jan;118(1):75-86 PMID: 8608934
  15. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans.
    Genetics. 1996 Jul;143(3):1207-18 PMID: 8807294
  16. Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1.
    Dev Genet. 1996;18(2):114-24 PMID: 8934873
  17. Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance.
    J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):B48-52 PMID: 9008657
  18. Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity.
    C R Acad Sci III. 1997 Mar;320(3):215-21 PMID: 9183440
  19. Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid.
    Exp Gerontol. 1996 Nov-Dec;31(6):699-704 PMID: 9415098
  20. Hormesis and the antiaging action of dietary restriction.
    Exp Gerontol. 1998 Jan-Mar;33(1-2):61-6 PMID: 9467717
  21. Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages.
    Mech Ageing Dev. 1998 Aug 1;104(1):59-73 PMID: 9751432
  22. The genetics of caloric restriction in Caenorhabditis elegans.
    Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13091-6 PMID: 9789046
  23. Evidence that hormesis represents an "overcompensation" response to a disruption in homeostasis.
    Ecotoxicol Environ Saf. 1999 Feb;42(2):135-7 PMID: 10051361
  24. The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway.
    Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7427-32 PMID: 10377431
  25. Anticonvulsant medications extend worm life-span.
    Science. 2005 Jan 14;307(5707):258-62 PMID: 15653505
  26. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.
    Nat Genet. 2005 Aug;37(8):894-8 PMID: 16041374
  27. The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
    Aging Cell. 2006 Apr;5(2):127-38 PMID: 16626392
  28. The spe-10 mutant has longer life and increased stress resistance.
    Neurobiol Aging. 1999 Sep-Oct;20(5):503-12 PMID: 10638523
  29. The marginalization of hormesis.
    Hum Exp Toxicol. 2000 Jan;19(1):32-40 PMID: 10745293
  30. Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment.
    Risk Anal. 1999 Apr;19(2):261-81 PMID: 10765404
  31. Hormesis is the beneficial action resulting from the response of an organism to a low-intensity stressor.
    Hum Exp Toxicol. 2000 Jun;19(6):340-1 PMID: 10962503
  32. Extension of life-span with superoxide dismutase/catalase mimetics.
    Science. 2000 Sep 1;289(5484):1567-9 PMID: 10968795
  33. Oxidants, oxidative stress and the biology of ageing.
    Nature. 2000 Nov 9;408(6809):239-47 PMID: 11089981
  34. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans.
    FASEB J. 2001 Mar;15(3):627-34 PMID: 11259381
  35. Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.
    Mech Ageing Dev. 2001 Sep 15;122(13):1477-95 PMID: 11470134
  36. Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.
    Exp Gerontol. 2001 Nov;36(10):1609-17 PMID: 11672983
  37. Heating stress patterns in Caenorhabditis elegans longevity and survivorship.
    Biogerontology. 2001;2(1):35-44 PMID: 11708615
  38. Longevity and aging: beneficial effects of exposure to mild stress.
    Biogerontology. 2000;1(1):15-29 PMID: 11707916
  39. Hormesis and debilitation effects in stress experiments using the nematode worm Caenorhabditis elegans: the model of balance between cell damage and HSP levels.
    Exp Gerontol. 2001 Dec;37(1):57-66 PMID: 11738147
  40. Heat shock changes the heterogeneity distribution in populations of Caenorhabditis elegans: does it tell us anything about the biological mechanism of stress response?
    J Gerontol A Biol Sci Med Sci. 2002 Mar;57(3):B83-92 PMID: 11867644
  41. Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity.
    J Gerontol A Biol Sci Med Sci. 2002 Mar;57(3):B109-14 PMID: 11867647
  42. Defining hormesis.
    Hum Exp Toxicol. 2002 Feb;21(2):91-7 PMID: 12102503
  43. Transcriptional profile of aging in C. elegans.
    Curr Biol. 2002 Sep 17;12(18):1566-73 PMID: 12372248
  44. Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.
    Exp Gerontol. 2003 Sep;38(9):947-54 PMID: 12954481
  45. Hormesis in Caenorhabditis elegans dauer-defective mutants.
    Biogerontology. 2003;4(4):203-14 PMID: 14501184
  46. The hunt for the record life span in Caenorhabditis elegans.
    J Gerontol A Biol Sci Med Sci. 2004 May;59(5):408-10 PMID: 15123748
  47. Heat tolerance changes with age in normal and irradiated Drosophila melanogaster.
    Exp Gerontol. 1973 Aug;8(4):207-17 PMID: 4199650
  48. Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span.
    Mech Ageing Dev. 1977 Nov-Dec;6(6):413-29 PMID: 926867
  49. Genetic analysis of life-span in Caenorhabditis elegans.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6603-7 PMID: 6959141
  50. Cadmium acclimation and hormesis in Fundulus heteroclitus during fin regeneration.
    Environ Res. 1986 Apr;39(2):356-63 PMID: 3956462
  51. Hormetic effects in pharmacology: pharmacological inversions as prototypes for hormesis.
    Health Phys. 1987 May;52(5):527-30 PMID: 3570795
  52. Growth hormesis: a by-product of control.
    Health Phys. 1987 May;52(5):543-7 PMID: 2883157
  53. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
    J Gerontol. 1988 Jul;43(4):B102-9 PMID: 3385139
Article Info
Journal
Experimental gerontology
Abbr.
Exp Gerontol
ISSN
0531-5565
DOI
10.1016/j.exger.2006.09.004
Email
[email protected]
Published
2006-10-00
Epub
2006-00-24
Pages
935-9
Language
English
Region
England
NLM ID
0047061
PMCID
PMC1847401
Subset
IM
Grants
NIA NIH HHS · P01 AG008761 · United States
NIA NIH HHS · R01 AG016219 · United States
External Links
PubMed source DOI: 10.1016/j.exger.2006.09.004 PMC Full Text View journal details
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