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PMID: 17093940 Published · ppublish English Comparative Study Letter Research Support, Non-U.S. Gov't

No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects.

Diabetologia ·Vol. 50 ·No. 1 ·2007-01-00 ·Pages 214-6

Cauchi S, Vaxillaire M, Choquet H, Durand E, Duval A, Polak M, Froguel P

Abstract

暂无摘要

MeSH Terms
Adolescent Adult Child Child, Preschool Diabetes Mellitus, Type 1/genetics,physiopathology Diabetes Mellitus, Type 2/genetics,physiopathology Female France Humans Infant Insulin-Secreting Cells/physiology Male Middle Aged Mutation/genetics Polymorphism, Single Nucleotide/genetics TCF Transcription Factors/genetics,physiology Transcription Factor 7-Like 2 Protein Whites/genetics
Chemicals
TCF Transcription Factors TCF7L2 protein, human Transcription Factor 7-Like 2 Protein
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Cauchi S
Vaxillaire M
Choquet H
Durand E
Duval A
Polak M
Froguel P
References (11)
11 references, click to expand
  1. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
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  2. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.
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  3. Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
    Diabetes. 2006 Oct;55(10):2903-8 PMID: 17003360
  4. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
    Nat Genet. 2006 Mar;38(3):320-3 PMID: 16415884
  5. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
    N Engl J Med. 2006 Jul 20;355(3):241-50 PMID: 16855264
  6. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
    N Engl J Med. 1993 Mar 11;328(10):697-702 PMID: 8433729
  7. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
    Diabetes. 2006 Sep;55(9):2640-4 PMID: 16936215
  8. The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.
    Cancer Res. 2000 Jul 15;60(14):3872-9 PMID: 10919662
  9. Genetic basis of maturity-onset diabetes of the young.
    Endocrinol Metab Clin North Am. 2006 Jun;35(2):371-84, x PMID: 16632099
  10. A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
    Diabetes. 2003 Mar;52(3):872-81 PMID: 12606533
  11. Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients.
    Diabetes. 2004 Oct;53(10):2719-22 PMID: 15448107
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/s00125-006-0505-z
Published
2007-01-00
Epub
2006-00-09
Pages
214-6
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/s00125-006-0505-z View journal details
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