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PMID: 17108952 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

The receptors and cells for mammalian taste.

Nature ·Vol. 444 ·No. 7117 ·2006-11-16 ·Pages 288-94

Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS

Abstract

The emerging picture of taste coding at the periphery is one of elegant simplicity. Contrary to what was generally believed, it is now clear that distinct cell types expressing unique receptors are tuned to detect each of the five basic tastes: sweet, sour, bitter, salty and umami. Importantly, receptor cells for each taste quality function as dedicated sensors wired to elicit stereotypic responses.

MeSH Terms
Animals Humans Receptors, G-Protein-Coupled/metabolism Signal Transduction Taste/physiology Taste Buds/metabolism
Chemicals
Receptors, G-Protein-Coupled
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chandrashekar Jayaram
Howard Hughes Medical Institute and Departments of Neurobiology and Neurosciences, University of California at San Diego, La Jolla, California 92093-0649, USA.
Hoon Mark A
Ryba Nicholas J P
Zuker Charles S
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2006-11-16
Pages
288-94
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Intramural NIH HHS · United States
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