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PMID: 171138 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hormone receptors, 5. Binding of glucagon and insulin to human circulating mononuclear cells in diabetes mellitus.

Endocrine research communications ·Vol. 2 ·No. 4-5 ·1975-00-00 ·Pages 367-76

Goldstein S, Blecher M, Binder R, Perrino PV, Recant L

Abstract

Preparations of human peripheral mononuclear leukocytes, containing over 85% lymphocytes, specifically bound glucagon and insulin. Binding of physiological concentrations of both hormones was seen to be substantially diminished when cells were derived from either adult-type diabetics or individuals with a unilateral genetic history of diabetes.

MeSH Terms

Binding Sites Diabetes Mellitus/blood,genetics Glucagon/blood Humans Insulin/blood Monocytes/metabolism Protein Binding Receptors, Cell Surface

Chemicals

Insulin Receptors, Cell Surface Glucagon

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Goldstein S

Blecher M

Binder R

Perrino P V

Recant L

Article Info

Journal

Endocrine research communications

Abbr.

Endocr Res Commun

ISSN

0093-6391

DOI

10.1080/07435807509089009

Published

1975-00-00

Pages

367-76

Language

English

Region

United States

NLM ID

0426337

Subset

External Links

PubMed source DOI: 10.1080/07435807509089009

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Hormone receptors, 5. Binding of glucagon and insulin to human circulating mononuclear cells in diabetes mellitus.

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