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PMID: 1712861 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages.

Journal of virology ·Vol. 65 ·No. 8 ·1991-08-00 ·Pages 4309-16

Shadduck PP, Weinberg JB, Haney AF, Bartlett JA, Langlois AJ, Bolognesi DP, Matthews TJ

Abstract

The influence of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of freshly isolated normal human peritoneal macrophages and blood monocytes was examined. Each of 14 HIV antibody-positive human serum samples was found to block the infection of four virus isolates (human T-cell lymphotropic virus type IIIBa-L [HTLV-IIIBa-L], HTLV-IIIB, D.U. 6587-7, and D.U. 7887-8) at serum dilutions ranging from 10(-1) to 10(-2). Three of these isolates (HTLV-IIIBa-L, D.U. 6587-7, and D.U. 7887-8) infected cultures of monocytes and macrophages rapidly and produced high levels of virus reverse transcriptase and p24 antigen. A fourth virus isolate (HTLV-IIIB) infected the monocytes and macrophages more slowly and produced low levels of viral protein. More dilute HIV antibody-positive sera had no significant effect on the overall level or rate of virus infection or expression. Complement did not appear to influence the course of infection by any combination of antisera or virus examined. Successful HIV-1 infection of the peritoneal macrophages and blood monocytes under the conditions tested showed strict dependence on CD4 since a recombinant CD4 polypeptide and an anti-CD4 monoclonal antibody effectively blocked the process.

MeSH Terms
Cells, Cultured Complement System Proteins/physiology Fluorescent Antibody Technique HIV Antibodies/immunology,physiology HIV-1/immunology,physiology Humans Kinetics Macrophages/microbiology Monocytes/microbiology Peritoneal Cavity/cytology RNA-Directed DNA Polymerase/biosynthesis
Chemicals
HIV Antibodies Complement System Proteins RNA-Directed DNA Polymerase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Shadduck P P
Department of Surgery, Duke University, Durham, North Carolina.
Weinberg J B
Haney A F
Bartlett J A
Langlois A J
Bolognesi D P
Matthews T J
References (50)
50 references, click to expand
  1. In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV).
    J Immunol. 1986 Jul 1;137(1):323-9 PMID: 3011909
  2. A human immunodeficiency virus type 1 (HIV-1) infection-enhancing factor in seropositive sera.
    Biochem Biophys Res Commun. 1987 Dec 16;149(2):693-9 PMID: 3426595
  3. Structure and function of human and murine receptors for IgG.
    Annu Rev Immunol. 1988;6:251-81 PMID: 2968084
  4. HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex.
    Nature. 1985 Jul 4-10;316(6023):72-4 PMID: 2989707
  5. Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients.
    Nature. 1985 Jul 4-10;316(6023):69-72 PMID: 2989706
  6. The Walter Reed staging classification for HTLV-III/LAV infection.
    N Engl J Med. 1986 Jan 9;314(2):131-2 PMID: 2934633
  7. Membrane complement receptors specific for bound fragments of C3.
    Adv Immunol. 1985;37:217-67 PMID: 3159188
  8. Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.
    Br Med J (Clin Res Ed). 1986 Dec 6;293(6560):1459-62 PMID: 3099912
  9. Quantitative immunocytofluorographic analysis of CD4 surface antigen expression and HIV infection of human peripheral blood monocyte/macrophages.
    AIDS Res Hum Retroviruses. 1987 Summer;3(2):135-45 PMID: 3113464
  10. Complement-mediated, antibody-dependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA syntheses and infectious virus release.
    J Acquir Immune Defic Syndr. 1989;2(1):33-42 PMID: 2465404
  11. Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein.
    Proc Natl Acad Sci U S A. 1986 Dec;83(24):9709-13 PMID: 2432599
  12. Epitopes of the CD4 antigen and HIV infection.
    Science. 1986 Nov 28;234(4780):1120-3 PMID: 2430333
  13. Enhancement of human immunodeficiency virus (HIV) replication in human monocytes by low titres of anti-HIV antibodies in vitro.
    Scand J Immunol. 1989 Oct;30(4):425-34 PMID: 2554488
  14. Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens.
    J Immunol. 1985 Oct;135(4):2687-94 PMID: 2411809
  15. The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells.
    Science. 1989 Jun 16;244(4910):1357-60 PMID: 2786647
  16. Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4710-4 PMID: 2471977
  17. Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees.
    Nature. 1987 Aug 20-26;328(6132):721-3 PMID: 3475581
  18. The role of mononuclear phagocytes in HTLV-III/LAV infection.
    Science. 1986 Jul 11;233(4760):215-9 PMID: 3014648
  19. Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein.
    Science. 1986 Jul 11;233(4760):209-12 PMID: 3014647
  20. SIV infected rhesus macaques: an AIDS model for immunoprevention and immunotherapy.
    Adv Exp Med Biol. 1989;251:279-93 PMID: 2558527
  21. A formalin-inactivated whole SIV vaccine confers protection in macaques.
    Science. 1989 Dec 8;246(4935):1293-7 PMID: 2555923
  22. Vaccine protection against simian immunodeficiency virus infection.
    Proc Natl Acad Sci U S A. 1989 Aug;86(16):6353-7 PMID: 2548210
  23. Structural features of CD4 required for binding to HIV.
    J Immunol. 1989 Apr 1;142(7):2250-6 PMID: 2538505
  24. HIV infection of monocytic cells: rôle of antibody-mediated virus binding to Fc-gamma receptors.
    AIDS. 1989 Mar;3(3):125-33 PMID: 2523711
  25. The macrophage in the persistence and pathogenesis of HIV infection.
    AIDS. 1989 Aug;3(8):475-95 PMID: 2508709
  26. Variations in CD4 expression by human monocytes and macrophages and their relationships to infection with the human immunodeficiency virus.
    J Gen Virol. 1989 Oct;70 ( Pt 10):2661-72 PMID: 2677236
  27. Will antibody-dependent enhancement of HIV-1 infection be a problem with AIDS vaccines?
    Lancet. 1988 Apr 9;1(8589):830-1 PMID: 2895350
  28. Antibody-dependent enhancement of human immunodeficiency virus type 1 infection.
    Lancet. 1988 Apr 9;1(8589):790-4 PMID: 2895317
  29. In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity.
    J Virol. 1988 Jan;62(1):139-47 PMID: 3257102
  30. A soluble form of CD4 (T4) protein inhibits AIDS virus infection.
    Nature. 1988 Jan 7;331(6151):82-4 PMID: 3257544
  31. Another glitch for AIDS vaccines?
    Science. 1988 Jul 29;241(4865):533-4 PMID: 3399887
  32. Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization.
    Proc Natl Acad Sci U S A. 1988 Apr;85(8):2815-9 PMID: 3357892
  33. The chemistry and biology of complement receptors.
    Springer Semin Immunopathol. 1984;7(2-3):221-49 PMID: 6238434
  34. Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression.
    J Clin Invest. 1987 Aug;80(2):316-24 PMID: 3497176
  35. Phenotypic characterization of gamma interferon-induced human monocyte polykaryons.
    Blood. 1985 Dec;66(6):1241-6 PMID: 3933591
  36. Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees.
    J Virol. 1990 Aug;64(8):3674-8 PMID: 2370678
  37. Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals.
    J Virol. 1990 May;64(5):2290-7 PMID: 2157886
  38. HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor.
    Nature. 1990 Feb 15;343(6259):659-61 PMID: 2154697
  39. Discriminating between protective and enhancing HIV antibodies.
    AIDS Res Hum Retroviruses. 1990 Feb;6(2):243-9 PMID: 2109624
  40. Inhibition of serum-enhanced HIV-1 infection of U937 monocytoid cells by recombinant soluble CD4 and anti-CD4 monoclonal antibody.
    AIDS Res Hum Retroviruses. 1990 May;6(5):629-39 PMID: 2361075
  41. Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 enhance HIV-1 infection in vitro.
    Proc Natl Acad Sci U S A. 1990 Apr;87(8):3185-9 PMID: 2326277
  42. Infection of monocytes by human immunodeficiency virus type 1 blocked by inhibitors of CD4-gp120 binding, even in the presence of enhancing antibodies.
    J Exp Med. 1990 Apr 1;171(4):1043-56 PMID: 2324685
  43. Serum enhancement of human immunodeficiency virus (HIV) infection correlates with disease in HIV-infected individuals.
    J Virol. 1990 Apr;64(4):1437-40 PMID: 2319642
  44. Effects of recombinant soluble CD4 (rCD4) on HIV-1 infection of monocyte/macrophages.
    J Infect Dis. 1990 Jan;161(1):1-6 PMID: 2295841
  45. Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.
    J Virol. 1981 Apr;38(1):239-48 PMID: 6165830
  46. Spontaneous tumor cell killing by human blood monocytes and human peritoneal macrophages: lack of alteration by endotoxin or quenchers of reactive oxygen species.
    J Natl Cancer Inst. 1983 Jun;70(6):1005-10 PMID: 6574267
  47. Long-term human peripheral blood monocyte cultures: establishment, metabolism and morphology of primary human monocyte-macrophage cell cultures.
    Immunology. 1979 Oct;38(2):401-11 PMID: 389789
  48. The separation, long-term cultivation, and maturation of the human monocyte.
    J Exp Med. 1977 Dec 1;146(6):1613-26 PMID: 925613
  49. Prevalence, clinical significance, and strain specificity of neutralizing antibody to the human immunodeficiency virus.
    J Infect Dis. 1987 Aug;156(2):268-72 PMID: 3474300
  50. Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry.
    Science. 1988 Oct 28;242(4878):580-3 PMID: 2972065
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.8.4309-4316.1991
Published
1991-08-00
Pages
4309-16
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC248869
Subset
IM
Grants
NIAID NIH HHS · AI 07922 · United States
NIAMS NIH HHS · AR 39162 · United States
NCI NIH HHS · CA 09307 · United States
External Links
PubMed source DOI: 10.1128/JVI.65.8.4309-4316.1991 PMC Full Text View journal details
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