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PMID: 17145549 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Tumor macrophage redox and effector mechanisms associated with hypoxia.

Free radical biology & medicine ·Vol. 41 ·No. 11 ·2006-12-01 ·Pages 1621-8

Espey MG

Abstract

Monocytes are recruited from the circulation into solid tumors where they differentiate into macrophages with unique phenotypes. While macrophages utilize oxygen in a broad range of immune effector functions, the generation of reactive oxygen and nitrogen oxide species is less clear in the setting of hypoxia, which can be a prominent feature of solid tumors. The relationships among innate immunity, redox systems, and the plasticity of phenotypic changes tumor-associated macrophages undergo in conjunction with tumor hypoxia will be examined.

MeSH Terms
Animals Humans Hypoxia/etiology,pathology Immunity, Innate Macrophages/metabolism,pathology Neoplasms/complications,pathology,therapy Oxidation-Reduction
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Espey Michael Graham
Radiation Biology Branch, National Cancer Institute, NIH, 10/B3-B69, 9000 Rockville Pike, Bethesda, MD 20892, USA. [email protected]
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Article Info
Journal
Free radical biology & medicine
Abbr.
Free Radic Biol Med
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2006.08.026
Email
[email protected]
Published
2006-12-01
Epub
2006-00-16
Pages
1621-8
Language
English
Region
United States
NLM ID
8709159
PMCID
PMC1934898
Subset
IM
Grants
Intramural NIH HHS · Z99 DK999999 · United States
External Links
PubMed source DOI: 10.1016/j.freeradbiomed.2006.08.026 PMC Full Text View journal details
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