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PMID: 17147916 Published · ppublish English Journal Article Review

Inflammation and the metabolic syndrome: role of angiotensin II and oxidative stress.

Current hypertension reports ·Vol. 8 ·No. 3 ·2006-06-00 ·Pages 191-8

Ferder L, Inserra F, Martínez-Maldonado M

Abstract

Excess body weight, high blood pressure, and insulin resistance together have been denominated the metabolic syndrome. In this review, we analyze the potential role of angiotensin II (Ang II) and reactive oxygen species in mediating inflammation in the metabolic syndrome. Ang II induces pro-inflammatory genes and other pro-inflammatory substances and increases oxidative stress that could damage endothelium, myocardium, and renal tissue. Activation of nuclear factor-kappaB and NAD(P)H oxidase are fundamental steps in these pro-inflammatory mechanisms in which intramitochondrial oxidative stress could play a critical role. This sequence of events might explain why reduction in Ang II synthesis by angiotensin-converting enzyme inhibitors (ACEIs) and Ang II type 1 (AT1) receptor blockers (ARBs) have a protective effect against cardiovascular disease.

MeSH Terms
Angiotensin II/drug effects,metabolism Angiotensin II Type 1 Receptor Blockers/therapeutic use Angiotensin-Converting Enzyme Inhibitors/therapeutic use Animals C-Reactive Protein/metabolism Humans Hypertension/drug therapy,metabolism,physiopathology Inflammation Mediators/metabolism Metabolic Syndrome/drug therapy,metabolism,physiopathology NADPH Oxidases/metabolism Oxidative Stress/drug effects Reactive Nitrogen Species/metabolism Reactive Oxygen Species/metabolism
Chemicals
Angiotensin II Type 1 Receptor Blockers Angiotensin-Converting Enzyme Inhibitors Inflammation Mediators Reactive Nitrogen Species Reactive Oxygen Species Angiotensin II C-Reactive Protein NADPH Oxidases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ferder León
Department of Physiology, Ponce School of Medicine, Dr. Ana Perez Marchand Street, PO Box 7004, Ponce, PR00732-7004, USA. [email protected]
Inserra Felipe
Martínez-Maldonado Manuel
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Article Info
Journal
Current hypertension reports
Abbr.
Curr Hypertens Rep
ISSN
1522-6417
DOI
10.1007/s11906-006-0050-7
Email
[email protected]
Published
2006-06-00
Pages
191-8
Language
English
Region
United States
NLM ID
100888982
Subset
IM
External Links
PubMed source DOI: 10.1007/s11906-006-0050-7 View journal details
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