Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus.

Vaccine ·Vol. 9 ·No. 7 ·1991-07-00 ·Pages 470-2

Etlinger HM, Altenburger W

Abstract

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector.

MeSH Terms

Animals Antibodies, Protozoan/biosynthesis Antibodies, Viral/biosynthesis Antigens, Protozoan/immunology Epitopes/immunology Immunization Kinetics Mice Mice, Inbred BALB C Plasmodium falciparum/immunology Protozoan Vaccines/immunology Vaccines, Synthetic/administration & dosage,immunology Vaccinia virus/immunology

Chemicals

Antibodies, Protozoan Antibodies, Viral Antigens, Protozoan Epitopes Protozoan Vaccines Vaccines, Synthetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Etlinger H M

Central Research Units, F. Hoffman-La Roche Ltd., Basel, Switzerland.

Altenburger W

Article Info

Journal

Vaccine

Abbr.

Vaccine

ISSN

0264-410X

DOI

10.1016/0264-410x(91)90030-a

Published

1991-07-00

Pages

470-2

Language

English

Region

Netherlands

NLM ID

8406899

Subset

External Links

PubMed source DOI: 10.1016/0264-410x(91)90030-a View journal details

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Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus.

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