Abstract
The rice (Oryza sativa) genome contains 1,429 protein kinases, the vast majority of which have unknown functions. We created a phylogenomic database (http://rkd.ucdavis.edu) to facilitate functional analysis of this large gene family. Sequence and genomic data, including gene expression data and protein-protein interaction maps, can be displayed for each selected kinase in the context of a phylogenetic tree allowing for comparative analysis both within and between large kinase subfamilies. Interaction maps are easily accessed through links and displayed using Cytoscape, an open source software platform. Chromosomal distribution of all rice kinases can also be explored via an interactive interface.
MeSH Terms
Amino Acid Motifs
Base Sequence
Chromosome Mapping
Chromosomes, Plant
DNA Transposable Elements/genetics
DNA, Plant
Databases, Factual
Genome, Plant
Molecular Sequence Data
Mutagenesis, Insertional
Oryza/classification,enzymology,genetics
Phosphotransferases/genetics,metabolism
Phylogeny
Protein Binding
Chemicals
DNA Transposable Elements
DNA, Plant
Phosphotransferases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dardick Christopher
United States Department of Agriculture-Agricultural Research Service, Appalachian Fruit Research Station, Kearneysville, West Virginia 25430, USA.
Chen Johann
Richter Todd
Ouyang Shu
Ronald Pamela
References (25)
25 references, click to expand
-
The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats.
Cell. 1994 Sep 23;78(6):1089-99
PMID: 7923358
-
Overexpression of a rice NPR1 homolog leads to constitutive activation of defense response and hypersensitivity to light.
Mol Plant Microbe Interact. 2005 Jun;18(6):511-20
PMID: 15986920
-
High throughput T-DNA insertion mutagenesis in rice: a first step towards in silico reverse genetics.
Plant J. 2004 Aug;39(3):450-64
PMID: 15255873
-
The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response.
Cell. 1995 Dec 15;83(6):925-35
PMID: 8521516
-
Receptor protein kinases--pattern recognition receptors in plant immunity.
Trends Plant Sci. 2006 Nov;11(11):519-22
PMID: 17030146
-
Protein-protein interactions of tandem affinity purification-tagged protein kinases in rice.
Plant J. 2006 Apr;46(1):1-13
PMID: 16553892
-
The protein kinase complement of the human genome.
Science. 2002 Dec 6;298(5600):1912-34
PMID: 12471243
-
Plant MPSS databases: signature-based transcriptional resources for analyses of mRNA and small RNA.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D731-5
PMID: 16381968
-
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Genome Res. 2003 Nov;13(11):2498-504
PMID: 14597658
-
Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
Science. 2003 Jul 18;301(5631):376-9
PMID: 12869764
-
Target site specificity of the Tos17 retrotransposon shows a preference for insertion within genes and against insertion in retrotransposon-rich regions of the genome.
Plant Cell. 2003 Aug;15(8):1771-80
PMID: 12897251
-
Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor kinase-like protein.
Plant J. 2004 Feb;37(4):517-27
PMID: 14756760
-
Genetically engineered broad-spectrum disease resistance in tomato.
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10300-5
PMID: 9707642
-
The PlantsP and PlantsT Functional Genomics Databases.
Nucleic Acids Res. 2003 Jan 1;31(1):342-4
PMID: 12520018
-
TIR-X and TIR-NBS proteins: two new families related to disease resistance TIR-NBS-LRR proteins encoded in Arabidopsis and other plant genomes.
Plant J. 2002 Oct;32(1):77-92
PMID: 12366802
-
Plant and animal pathogen recognition receptors signal through non-RD kinases.
PLoS Pathog. 2006 Jan;2(1):e2
PMID: 16424920
-
Comparative analysis of the receptor-like kinase family in Arabidopsis and rice.
Plant Cell. 2004 May;16(5):1220-34
PMID: 15105442
-
GenomePixelizer--a visualization program for comparative genomics within and between species.
Bioinformatics. 2002 Feb;18(2):335-6
PMID: 11847088
-
The gene FLORAL ORGAN NUMBER1 regulates floral meristem size in rice and encodes a leucine-rich repeat receptor kinase orthologous to Arabidopsis CLAVATA1.
Development. 2004 Nov;131(22):5649-57
PMID: 15509765
-
A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21.
Science. 1995 Dec 15;270(5243):1804-6
PMID: 8525370
-
Synergistic interaction of three ERECTA-family receptor-like kinases controls Arabidopsis organ growth and flower development by promoting cell proliferation.
Development. 2004 Apr;131(7):1491-501
PMID: 14985254
-
A B-lectin receptor kinase gene conferring rice blast resistance.
Plant J. 2006 Jun;46(5):794-804
PMID: 16709195
-
Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases.
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10763-8
PMID: 11526204
-
KinG: a database of protein kinases in genomes.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D153-5
PMID: 14681382
-
Interactions between the subunits of casein kinase II.
J Biol Chem. 1995 Jun 2;270(22):13017-21
PMID: 7768894