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PMID: 17172673 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The unfolded protein response.

Molecular biotechnology ·Vol. 34 ·No. 2 ·2006-10-00 ·Pages 279-90

Schröder M

Abstract

The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis, attenuation of general translation, and upregulation of ER-associated degradation to decrease the unfolded protein load of the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells from an organism or a population. In this review, I will summarize our current knowledge about signal transduction pathways involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol.

MeSH Terms
Animals Apoptosis Cell Nucleus/metabolism Endoplasmic Reticulum/metabolism Humans Protein Folding Recombinant Proteins/biosynthesis,chemistry,metabolism Signal Transduction
Chemicals
Recombinant Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schröder Martin
School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom. [email protected]
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Article Info
Journal
Molecular biotechnology
Abbr.
Mol Biotechnol
ISSN
1073-6085
DOI
10.1385/MB:34:2:279
Email
[email protected]
Published
2006-10-00
Pages
279-90
Language
English
Region
United States
NLM ID
9423533
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/C513418/1 · United Kingdom
External Links
PubMed source DOI: 10.1385/MB:34:2:279 View journal details
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