Translocation (10;17)(p15;q21) is a recurrent anomaly in acute myeloblastic leukemia.

Cancer genetics and cytogenetics ·Vol. 172 ·No. 1 ·2007-01-01 ·页码 74-6

Tempescul A, Guillerm G, Douet-Guilbert N, Morel F, Le Bris MJ, De Braekeleer M

Abstract

We report here two cases of patients with acute myeloblastic leukemia, type M1 (FAB classification), associated with a t(10;17)(p15;q21). Fluorescence in situ hybridization with the LSI PML/RARA dual-color probe showed the breakpoint to be distal to the RARA locus. Four other patients with this translocation have been reported, three of them having acute undifferentiated or poorly differentiated leukemia.

MeSH 主题词

Aged Chromosomes, Human, Pair 10/genetics Chromosomes, Human, Pair 17/genetics Humans In Situ Hybridization, Fluorescence Leukemia, Myeloid, Acute/genetics Male Neoplasm Proteins/genetics Neoplasm Recurrence, Local/genetics Nuclear Proteins/genetics Promyelocytic Leukemia Protein Receptors, Retinoic Acid/genetics Retinoic Acid Receptor alpha Transcription Factors/genetics Translocation, Genetic/genetics Tumor Suppressor Proteins/genetics

化学物质

Neoplasm Proteins Nuclear Proteins Promyelocytic Leukemia Protein RARA protein, human Receptors, Retinoic Acid Retinoic Acid Receptor alpha Transcription Factors Tumor Suppressor Proteins PML protein, human

作者与单位

共 6 位作者，点击展开单位 / ORCID

Tempescul Adrian

Department of Clinical Hematology, Institute of Cancerology and Hematology, CHU Morvan, Avenue Foch, 29609 Brest, France.

Guillerm Gaëlle

Douet-Guilbert Nathalie

Morel Frédéric

Le Bris Marie-Josée

De Braekeleer Marc

Article Info

Journal

Cancer genetics and cytogenetics

Abbr.

Cancer Genet Cytogenet

ISSN

0165-4608

DOI

10.1016/j.cancergencyto.2006.08.001

Published

2007-01-01

页码

74-6

Language

English

Country/Region

United States

NLM ID

7909240

External Links

PubMed source DOI: 10.1016/j.cancergencyto.2006.08.001 View journal details

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Translocation (10;17)(p15;q21) is a recurrent anomaly in acute myeloblastic leukemia.

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