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PMID: 1721107 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.

Nature ·Vol. 354 ·No. 6353 ·1991-12-12 ·Pages 453-9

Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CR, Rizza CR

Abstract

In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.

MeSH Terms

Amino Acid Sequence Base Sequence Epitopes/genetics,immunology Genetic Variation/genetics,immunology HIV/genetics,immunology HIV Core Protein p24/genetics,immunology HIV Infections/complications,immunology,microbiology HIV Seropositivity/immunology Hemophilia A/complications Humans Longitudinal Studies Molecular Sequence Data Mutation/genetics,immunology Peptide Fragments/immunology T-Lymphocytes, Cytotoxic/immunology,microbiology

Chemicals

Epitopes HIV Core Protein p24 Peptide Fragments

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Phillips R E

Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK.

Rowland-Jones S

Nixon D F

Gotch F M

Edwards J P

Ogunlesi A O

Elvin J G

Rothbard J A

Bangham C R

Rizza C R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/354453a0

Published

1991-12-12

Pages

453-9

Language

English

Region

England

NLM ID

0410462

Subset

Grants

Wellcome Trust · United Kingdom

Corrections

CommentIn

PMID: 1721106

External Links

PubMed source DOI: 10.1038/354453a0 View journal details

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Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.

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