Home LiteratureArticle Details
PMID: 17246098 Published · ppublish English Journal Article

Frequency of gamma-Ray Induced Specific Locus and Recessive Lethal Mutations in Mature Germ Cells of the Zebrafish, BRACHYDANIO RERIO.

Genetics ·Vol. 103 ·No. 1 ·1983-01-00 ·Pages 109-23

Chakrabarti S, Streisinger G, Singer F, Walker C

Abstract

Specific locus and recessive lethal mutations are induced by gamma-rays with approximately first order kinetics in the zebrafish (Brachydanio rerio) with frequencies of 4 x 10(-5) r(-1 ) and 4 x 10(-3) r(-1), respectively. The surprisingly low ratio (100:1) of recessive lethals to specific locus mutations may be due to the induction of large deficiencies by gamma-rays.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chakrabarti S
Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403.
Streisinger G
Singer F
Walker C
References (10)
10 references, click to expand
  1. Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse.
    Cell. 1979 Feb;16(2):225-37 PMID: 36985
  2. Is there a proportionality between the spontaneous and the X-ray-induction rates of mutations? Experiments with mutations at 13 X-chromosome loci in Drosophila melanogaster.
    Mutat Res. 1979 Jul;61(2):229-48 PMID: 113675
  3. Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women.
    Proc Natl Acad Sci U S A. 1977 Aug;74(8):3523-7 PMID: 269410
  4. X-ray-induced recessive lethal mutations in the mouse.
    Mutat Res. 1976 Jan;34(1):163-74 PMID: 943038
  5. Mutation Rates at Specific Autosomal Loci in the Mature and Immature Germ Cells of Drosophila Melanogaster.
    Genetics. 1954 May;39(3):409-28 PMID: 17247493
  6. Chromosomes of the zebra fish. A model for cytogenetic, embryologic, and ecologic study.
    J Hered. 1968 Nov-Dec;59(6):382-4 PMID: 5713937
  7. Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):4251-5 PMID: 6933474
  8. Production of clones of homozygous diploid zebra fish (Brachydanio rerio).
    Nature. 1981 May 28;291(5813):293-6 PMID: 7248006
  9. Induction of Mutations by gamma-Rays in Pregonial Germ Cells of Zebrafish Embryos.
    Genetics. 1983 Jan;103(1):125-36 PMID: 17246099
  10. Cytological observations of deletions in pachytene stages of oogenesis and spermatogenesis in the mouse.
    Chromosoma. 1976 Nov 29;58(4):377-86 PMID: 1001161
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
Published
1983-01-00
Pages
109-23
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1202016
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]