Home LiteratureArticle Details
PMID: 17277944 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Unique pattern of R-gene variation within populations in Arabidopsis.

Molecular genetics and genomics : MGG ·Vol. 277 ·No. 6 ·2007-06-00 ·Pages 619-29

Ding J, Zhang W, Jing Z, Chen JQ, Tian D

Abstract

An understanding of the variation pattern in disease resistance (R) genes is essential for its use in breeding programs aimed at neutralizing the threat of pathogens. Although the variation between populations is well known, there is little research about R-gene variation patterns within populations. Here, we investigate the polymorphism at three R-gene loci of 39 individual plants from nine populations of Arabidopsis thaliana. Our data suggest that alleles of each locus from individuals within a local population were either nearly identical, or highly diverse as ones between populations. The vast majority (92.5%) of within-population variation was shared globally, with high levels of allelic diversity (up to 11.7%) and abundant diverse-alleles. This unique pattern of within-population variation at R-loci suggests that individual plants within a population had the great potential to maintain a high level of globally-shared polymorphisms, and that the diversifying selection was the major force maintaining such polymorphisms. Consequently, the shared-polymorphism became recyclable for new R-genes, as the corresponding avirulence re-emerges in pathogen populations.

MeSH Terms
Alleles Arabidopsis/genetics Arabidopsis Proteins/genetics Genotype Immunity, Innate/genetics Molecular Sequence Data Phylogeny Plant Diseases/genetics,immunology Polymorphism, Genetic
Chemicals
Arabidopsis Proteins RPP13 protein, Arabidopsis RPP8 protein, Arabidopsis RPS2 protein, Arabidopsis
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ding Jing
State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China.
Zhang Weili
Jing Zhiqiang
Chen Jian-Qun
Tian Dacheng
References (38)
38 references, click to expand
  1. Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis.
    Plant Cell. 1999 Nov;11(11):2099-112 PMID: 10559437
  2. Genome-wide investigation on the genetic variations of rice disease resistance genes.
    Plant Mol Biol. 2006 Sep;62(1-2):181-93 PMID: 16915523
  3. Clusters of resistance genes in plants evolve by divergent selection and a birth-and-death process.
    Genome Res. 1998 Nov;8(11):1113-30 PMID: 9847076
  4. Estimating the recombination parameter of a finite population model without selection.
    Genet Res. 1987 Dec;50(3):245-50 PMID: 3443297
  5. Host-parasite coevolutionary conflict between Arabidopsis and downy mildew.
    Science. 2004 Dec 10;306(5703):1957-60 PMID: 15591208
  6. Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast.
    Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9757-62 PMID: 9275197
  7. Multiple genetic processes result in heterogeneous rates of evolution within the major cluster disease resistance genes in lettuce.
    Plant Cell. 2004 Nov;16(11):2870-94 PMID: 15494555
  8. The arms race is ancient history in Arabidopsis, the wildflower.
    Nat Rev Genet. 2001 Jul;2(7):516-27 PMID: 11433358
  9. Evolutionary dynamics of plant R-genes.
    Science. 2001 Jun 22;292(5525):2281-5 PMID: 11423651
  10. Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range.
    Mol Ecol. 2006 Apr;15(5):1405-18 PMID: 16626462
  11. Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes.
    Mol Genet Genomics. 2004 May;271(4):402-15 PMID: 15014983
  12. The coalescent process with selfing.
    Genetics. 1997 Jul;146(3):1185-95 PMID: 9215919
  13. Contrasting patterns of evolution between allelic groups at a single locus in Arabidopsis.
    Genetica. 2007 Mar;129(3):235-42 PMID: 16912841
  14. The molecular basis of co-evolution between Cladosporium fulvum and tomato.
    Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):409-12 PMID: 12448739
  15. Plant disease resistance genes: recent insights and potential applications.
    Trends Biotechnol. 2003 Apr;21(4):178-83 PMID: 12679066
  16. Plant pathogens and integrated defence responses to infection.
    Nature. 2001 Jun 14;411(6839):826-33 PMID: 11459065
  17. Natural Variation at the Pi-ta Rice Blast Resistance Locus.
    Phytopathology. 2003 Nov;93(11):1452-9 PMID: 18944075
  18. Novel disease resistance specificities result from sequence exchange between tandemly repeated genes at the Cf-4/9 locus of tomato.
    Cell. 1997 Dec 12;91(6):821-32 PMID: 9413991
  19. Understanding the functions of plant disease resistance proteins.
    Annu Rev Plant Biol. 2003;54:23-61 PMID: 14502984
  20. RCY1, an Arabidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism.
    Plant J. 2002 Dec;32(5):655-67 PMID: 12472683
  21. The sampling theory of selectively neutral alleles.
    Theor Popul Biol. 1972 Mar;3(1):87-112 PMID: 4667078
  22. Structure, function and evolution of plant disease resistance genes.
    Curr Opin Plant Biol. 2000 Aug;3(4):278-84 PMID: 10873844
  23. DnaSP, DNA polymorphism analyses by the coalescent and other methods.
    Bioinformatics. 2003 Dec 12;19(18):2496-7 PMID: 14668244
  24. Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and oomycete pathogens.
    Plant Cell. 2000 May;12(5):663-76 PMID: 10810142
  25. Comparative genetics of nucleotide binding site-leucine rich repeat resistance gene homologues in the genomes of two dicotyledons: tomato and arabidopsis.
    Genetics. 2000 May;155(1):309-22 PMID: 10790405
  26. The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsis thaliana.
    Genetics. 2004 Mar;166(3):1517-27 PMID: 15082565
  27. Identification of regions in alleles of the flax rust resistance gene L that determine differences in gene-for-gene specificity.
    Plant Cell. 1999 Mar;11(3):495-506 PMID: 10072407
  28. The pattern of polymorphism in Arabidopsis thaliana.
    PLoS Biol. 2005 Jul;3(7):e196 PMID: 15907155
  29. Finding new ways to fight plant diseases.
    Science. 2001 Jun 22;292(5525):2270-3 PMID: 11423646
  30. Genetic variation within and among populations of Arabidopsis thaliana.
    Genetics. 1998 Mar;148(3):1311-23 PMID: 9539444
  31. Pathogen population genetics, evolutionary potential, and durable resistance.
    Annu Rev Phytopathol. 2002;40:349-79 PMID: 12147764
  32. Genetic mechanisms and evolutionary significance of natural variation in Arabidopsis.
    Nature. 2006 Jun 22;441(7096):947-52 PMID: 16791187
  33. MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.
    Brief Bioinform. 2004 Jun;5(2):150-63 PMID: 15260895
  34. Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis.
    Plant Cell. 2003 Apr;15(4):809-34 PMID: 12671079
  35. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.
    Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 PMID: 7984417
  36. Unique evolutionary mechanism in R-genes under the presence/absence polymorphism in Arabidopsis thaliana.
    Genetics. 2006 Feb;172(2):1243-50 PMID: 16452149
  37. Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana.
    Genetics. 2003 Feb;163(2):735-46 PMID: 12618410
  38. Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis.
    Plant Cell. 1998 Nov;10(11):1861-74 PMID: 9811794
Article Info
Journal
Molecular genetics and genomics : MGG
Abbr.
Mol Genet Genomics
ISSN
1617-4615
DOI
10.1007/s00438-007-0213-5
Published
2007-06-00
Epub
2007-00-03
Pages
619-29
Language
English
Region
Germany
NLM ID
101093320
Subset
IM
Databases
GENBANK
EF368054, EF368055, EF368056, EF368057, EF368058, EF368059, EF368060, EF368061, EF368062, EF368063, EF368064, EF368065, EF368066, EF368067, EF368068, EF368069, EF368070, EF368071, EF368072, EF368073, EF368074, EF368075, EF368076, EF368077, EF368078, EF368079, EF368080, EF368081, EF368082, EF368083, EF368084, EF368085, EF368086, EF368087, EF368088, EF368089, EF368090, EF368091, EF368092, EF368093, EF368094, EF368095, EF368096, EF368097, EF368098, EF368099, EF368100, EF368101, EF368102, EF368103, EF368104, EF368105, EF368106, EF368107, EF368108, EF368109, EF368110, EF368111, EF368112, EF368113, EF368114, EF368115, EF368116, EF368117, EF368118, EF368119, EF368120, EF368121, EF368122, EF368123, EF368124, EF368125, EF368126, EF368127, EF368128, EF368129, EF368130, EF368131, EF368132, EF368133, EF368134, EF368135, EF368136, EF368137, EF368138, EF368139, EF368140, EF368141, EF368142, EF368143, EF368144, EF368145, EF368146, EF368147, EF368148, EF368149, EF368150, EF368151, EF368152, EF368153, EF368154, EF368155, EF368156, EF368157, EF368158
External Links
PubMed source DOI: 10.1007/s00438-007-0213-5 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2