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PMID: 17283194 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture.

Antimicrobial agents and chemotherapy ·Vol. 51 ·No. 4 ·2007-04-00 ·Pages 1497-9

Lee SM, Ender M, Adhikari R, Smith JM, Berger-Bächi B, Cook GM

Abstract

We examined the effect of introducing type I or IV staphylococcal cassette chromosome mec (SCCmec) elements on the growth yield of Staphylococcus aureus in glucose-limited continuous culture. Type I showed increased glucose consumption and ATP demand per gram of cells synthesized and decreased cell yield compared to those of the parent strain. In contrast, type IV SCCmec elements had no adverse energetic effect.

MeSH Terms
Chromosomes, Bacterial/genetics Culture Media Genes, Bacterial Glucose/metabolism Methicillin/pharmacology Methicillin Resistance/genetics Staphylococcus aureus/drug effects,genetics
Chemicals
Culture Media Glucose Methicillin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lee Sui Mae
Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P.O. Box 56, Dunedin, New Zealand.
Ender Miriam
Adhikari Rajan
Smith John M B
Berger-Bächi Brigitte
Cook Gregory M
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.01239-06
Published
2007-04-00
Epub
2007-00-05
Pages
1497-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC1855501
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.01239-06 PMC Full Text View journal details
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