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PMID: 17299456 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cell adhesion molecules: signalling functions at the synapse.

Nature reviews. Neuroscience ·Vol. 8 ·No. 3 ·2007-03-00 ·Pages 206-20

Dalva MB, McClelland AC, Kayser MS

Abstract

Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide a mechanical link between cells. In this review, we will discuss the roles these proteins have during development and at mature synapses. Synaptic adhesion proteins participate in the formation, maturation, function and plasticity of synaptic connections. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses.

MeSH Terms
Animals Cell Adhesion Molecules/classification,physiology Models, Biological Signal Transduction/physiology Synapses/physiology
Chemicals
Cell Adhesion Molecules
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dalva Matthew B
University of Pennsylvania Medical Center, Department of Neuroscience, BRB II/III, Room 1114, 421 Curie Blvd., Philadelphia, Pennsylvania 19104, USA. [email protected]
McClelland Andrew C
Kayser Matthew S
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-003X
DOI
10.1038/nrn2075
Email
[email protected]
Published
2007-03-00
Epub
2007-00-14
Pages
206-20
Language
English
Region
England
NLM ID
100962781
PMCID
PMC4756920
Subset
IM
Grants
NIDA NIH HHS · R01 DA022727 · United States
NIDA NIH HHS · R01 DA022727-02 · United States
External Links
PubMed source DOI: 10.1038/nrn2075 PMC Full Text View journal details
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