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PMID: 1730255 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Liposome-mediated delivery stimulates a class I-restricted cytotoxic T cell response to soluble antigen.

European journal of immunology ·Vol. 22 ·No. 1 ·1992-01-00 ·Pages 287-90

Lopes LM, Chain BM

Abstract

Most soluble protein antigens are poor at priming class I-restricted cytotoxic cell activity. In this study we show that incorporation of one protein, ovalbumin, into liposomes converts this antigen into an effective stimulator of antigen-specific cytotoxicity. The mechanisms responsible for this phenomenon are discussed.

MeSH Terms

Animals Drug Carriers Histocompatibility Antigens Class I/immunology Liposomes/administration & dosage Mice Ovalbumin/administration & dosage,immunology Peptide Fragments/immunology T-Lymphocytes, Cytotoxic/immunology

Chemicals

Drug Carriers Histocompatibility Antigens Class I Liposomes Peptide Fragments Ovalbumin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lopes L M

Dept. Biology, University College of London.

Chain B M

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/eji.1830220143

Published

1992-01-00

Pages

287-90

Language

English

Region

Germany

NLM ID

1273201

Subset

External Links

PubMed source DOI: 10.1002/eji.1830220143 View journal details

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Liposome-mediated delivery stimulates a class I-restricted cytotoxic T cell response to soluble antigen.

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