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PMID: 17306511 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

TRPML and lysosomal function.

Biochimica et biophysica acta ·Vol. 1772 ·No. 8 ·2007-08-00 ·Pages 851-8

Zeevi DA, Frumkin A, Bach G

Abstract

Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this protein and the rest of the mucolipin family.

MeSH Terms

Animals Humans Lysosomes/genetics,metabolism,physiology Models, Biological Protein Binding Protein Transport TRPM Cation Channels/genetics,metabolism,physiology Transient Receptor Potential Channels/genetics,metabolism,physiology

Chemicals

MCOLN1 protein, human MCOLN3 protein, human Mcoln2 protein, human TRPM Cation Channels Transient Receptor Potential Channels

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zeevi David A

Department of Human Genetics, Hadassah Hebrew University Hospital, Jerusalem, Israel.

Frumkin Ayala

Bach Gideon

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/j.bbadis.2007.01.004

Published

2007-08-00

Epub

2007-00-19

Pages

851-8

Language

English

Region

Netherlands

NLM ID

0217513

Subset

External Links

PubMed source DOI: 10.1016/j.bbadis.2007.01.004

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