Paradoxical response to dopamine agonists in tardive dyskinesia.

The American journal of psychiatry ·Vol. 134 ·No. 7 ·1977-07-00 ·Pages 785-9

Carroll BJ, Curtis GC, Kokmen E

Abstract

The authors conducted an extensive pharmacological analysis of a patient severely affected by tardive dyskinesia. No drug treatment gave lasting clinical improvement. Several agents recently recommended for this condition, dimethyl aminoethanol, clozapine, and thioridazine, failed to modify the dyskinesia. Reserpine caused a worsening of the symptoms. A paradoxical and unexpected improvement was observed with apomorphine injections and with low-dosage oral L-dopa. These two drugs may have acted by stimulating presynaptic inhibitory dopamine receptors.

MeSH Terms

Adrenergic alpha-Agonists/therapeutic use Adult Amantadine/therapeutic use Apomorphine/therapeutic use Benztropine/therapeutic use Clozapine/therapeutic use Deanol/therapeutic use Dextroamphetamine/therapeutic use Dose-Response Relationship, Drug Drug Antagonism Drug Tolerance Dyskinesia, Drug-Induced/drug therapy Female Haloperidol/therapeutic use Humans Levodopa/administration & dosage,therapeutic use Physostigmine/therapeutic use Receptors, Dopamine/drug effects Reserpine/adverse effects Stimulation, Chemical Thioridazine/therapeutic use

Chemicals

Adrenergic alpha-Agonists Receptors, Dopamine Benztropine Deanol Levodopa Reserpine Physostigmine Amantadine Clozapine Haloperidol Apomorphine Thioridazine Dextroamphetamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Carroll B J

Curtis G C

Kokmen E

Article Info

Journal

The American journal of psychiatry

Abbr.

Am J Psychiatry

ISSN

0002-953X

DOI

10.1176/ajp.134.7.785

Published

1977-07-00

Pages

785-9

Language

English

Region

United States

NLM ID

0370512

Subset

External Links

PubMed source DOI: 10.1176/ajp.134.7.785 View journal details

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Paradoxical response to dopamine agonists in tardive dyskinesia.

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