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PMID: 17330069 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling.

EMBO reports ·Vol. 8 ·No. 3 ·2007-03-00 ·Pages 241-6

Krauss M, Haucke V

Abstract

Phosphoinositides (PIs) have long been known to have important roles in cell signalling. During the past decade, it has become clear that these lipids also act as constitutive signals that aid in defining organelle identity, and are short-lived recruiters and regulators of cytoskeletal and membrane dynamics. Recent studies have provided important clues as to how regulated activation of PI-metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different cell physiological functions.

MeSH Terms
1-Phosphatidylinositol 4-Kinase/metabolism Membrane Transport Proteins/metabolism Models, Biological Phosphatidylinositols/metabolism Phosphoric Monoester Hydrolases/genetics,metabolism Protein Structure, Tertiary Protein Transport/physiology Signal Transduction/physiology
Chemicals
Membrane Transport Proteins Phosphatidylinositols 1-Phosphatidylinositol 4-Kinase Phosphoric Monoester Hydrolases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Krauss Michael
Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany.
Haucke Volker
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7400919
Published
2007-03-00
Pages
241-6
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1808040
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7400919 PMC Full Text View journal details
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