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PMID: 17340123 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.

Diabetologia ·Vol. 50 ·No. 5 ·2007-05-00 ·Pages 980-4

Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S

Abstract

The transcription factor 7-like 2 gene (TCF7L2) has been shown to be strongly associated with an increased risk of type 2 diabetes in white populations. To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population. We analysed four SNPs (rs12255372, rs7903146, rs7901695 and rs11196205) and one tetranucleotide repeat polymorphism (DG10S478) in 1,630 Japanese subjects with type 2 diabetes and 1,064 control subjects. All investigated polymorphisms were significantly associated with type 2 diabetes, and rs12255372 showed the strongest association (T vs G, chi2 = 9.20, p = 0.0024, odds ratio = 1.70, 95% CI = 1.20-2.41), although the frequency of the risk allele in our population was much lower than that in white populations. The microsatellite polymorphism showed an almost complete linkage disequilibrium to rs1255372 when the alleles with longer repeats (+8, +12) were considered as minor alleles and showed an association with type 2 diabetes (chi2 = 5.34, p = 0.021, odds ratio = 1.50, 95% CI = 1.06-2.12). These results indicate that TCF7L2 might be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities.

MeSH Terms
Aged Asians DNA/blood,genetics,isolation & purification Diabetes Mellitus, Type 2/epidemiology,genetics Ethnicity/statistics & numerical data Female Genetic Linkage Genetic Predisposition to Disease Genotype Glycated Hemoglobin A/analysis Humans Japan/epidemiology Male Middle Aged Polymorphism, Single Nucleotide Risk Assessment TCF Transcription Factors/genetics Transcription Factor 7-Like 2 Protein
Chemicals
Glycated Hemoglobin A TCF Transcription Factors TCF7L2 protein, human Transcription Factor 7-Like 2 Protein DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hayashi T
Laboratory for Diabetic Nephropathy, SNP Research Centre, The Institute of Physical and Chemical Research, Yokohama, Kanagawa 230-0045, Japan.
Iwamoto Y
Kaku K
Hirose H
Maeda S
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/s00125-007-0618-z
Published
2007-05-00
Epub
2007-00-06
Pages
980-4
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/s00125-007-0618-z View journal details
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