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PMID: 17360461 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 104 ·No. 10 ·2007-03-06 ·Pages 3967-72

Sharma P, Shen Y, Wen S, Yamada S, Jungbluth AA, Gnjatic S, Bajorin DF, Reuter VE, Herr H, Old LJ, Sato E

Abstract

Tumor-infiltrating cytotoxic T lymphocytes (TILs), including CD8 TILs, have been associated with favorable clinical outcomes in multiple tumor types. Tumor-infiltrating CD8 T cells and major histocompatibility complex (MHC) class I expression in urothelial carcinoma (UC) have not been previously reported. Most immune responses are mediated by local cytotoxic lymphocytes (CD8 T cells), which can eradicate tumor cells by recognizing tumor-associated antigens presented by MHC class I molecules. Here we analyzed the presence of intratumoral CD8 T cells, the expression of MHC class I antigen, and the expression of the NY-ESO-1 tumor antigen in UC samples and correlated our findings with clinical outcome. Immunohistochemical staining for intratumoral CD8 T cells in tissue samples from 69 patients with UC showed that patients with advanced UC (pT2, pT3, or pT4) and higher numbers of CD8 TILs within the tumor (> or =8) had better disease-free survival (P < 0.001) and overall survival (P = 0.018) than did patients with similar-staged UC and fewer intratumoral CD8 TILs. We conclude that the extent of intratumoral CD8 TILs is an important prognostic indicator in advanced UC.

MeSH Terms
Antigens, Neoplasm/biosynthesis CD8 Antigens/biosynthesis CD8-Positive T-Lymphocytes/metabolism Carcinoma/blood,immunology,mortality Cell Line, Tumor Disease-Free Survival Female Genes, MHC Class I Humans Immunohistochemistry Lymphocytes, Tumor-Infiltrating/metabolism Male Muscles/metabolism Prognosis Treatment Outcome Urinary Bladder Neoplasms/immunology,metabolism,mortality
Chemicals
Antigens, Neoplasm CD8 Antigens
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Sharma Padmanee
Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. [email protected]
Shen Yu
Wen Sijin
Yamada Sachiko
Jungbluth Achim A
Gnjatic Sacha
Bajorin Dean F
Reuter Victor E
Herr Harry
Old Lloyd J
Sato Eiichi
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0611618104
Email
[email protected]
Published
2007-03-06
Epub
2007-00-27
Pages
3967-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1820692
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0611618104 PMC Full Text View journal details
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