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PMID: 17367534 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Reactome: a knowledge base of biologic pathways and processes.

Genome biology ·Vol. 8 ·No. 3 ·2007-00-00 ·Pages R39

Vastrik I, D'Eustachio P, Schmidt E, Joshi-Tope G, Gopinath G, Croft D, de Bono B, Gillespie M, Jassal B, Lewis S, Matthews L, Wu G, Birney E, Stein L

Abstract

Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.

MeSH Terms
Animals Computational Biology/methods Databases as Topic Humans Internet Knowledge Bases Metabolic Networks and Pathways Microarray Analysis Saccharomyces cerevisiae Systems Biology
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Vastrik Imre
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. [email protected]
D'Eustachio Peter
Schmidt Esther
Joshi-Tope Geeta
Gopinath Gopal
Croft David
de Bono Bernard
Gillespie Marc
Jassal Bijay
Lewis Suzanna
Matthews Lisa
Wu Guanming
Birney Ewan
Stein Lincoln
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
DOI
10.1186/gb-2007-8-3-r39
Email
[email protected]
Published
2007-00-00
Pages
R39
Language
English
Region
England
NLM ID
100960660
PMCID
PMC1868929
Subset
IM
Grants
NHGRI NIH HHS · R01 HG002639 · United States
NHGRI NIH HHS · U41 HG003751 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1186/gb-2007-8-3-r39 PMC Full Text View journal details
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