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PMID: 17395265 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Hippocampal formation: shedding light on the influence of sex and stress on the brain.

Brain research reviews ·Vol. 55 ·No. 2 ·2007-10-00 ·Pages 343-55

McEwen BS, Milner TA

Abstract

The hippocampus is a malleable brain region that responds to external agents such as hormones and stressors. Investigations that began in our laboratories with the Golgi technique and an appreciation of hippocampal neuroanatomy at the light and electron microscopic levels have led us down a path that has uncovered unexpected structural plasticity in the adult brain along with unanticipated cellular and molecular mechanisms of this plasticity and of hormone mediation of these effects. This chapter reviews the history of discoveries in our two laboratories involving the actions of estradiol and stress hormones on neuronal structure and function and then discusses the insight to hormone-brain interactions that this has engendered. These discoveries have led us to a new view of brain structural plasticity and the role and mechanism of steroid hormone action involving both genomic and non-genomic pathways. This new view is consistent with the predictions of Cajal in his book "The Structure of Ammon's horn", 1892.

MeSH Terms
Animals Female Hippocampus/physiology,ultrastructure Humans Male Microscopy, Electron Neuronal Plasticity/physiology Receptors, Pituitary Hormone/metabolism Sex Characteristics Silver Staining Stress, Physiological/pathology,physiopathology
Chemicals
Receptors, Pituitary Hormone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McEwen Bruce S
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1300 York Avenue, New York, NY 10021, USA. [email protected]
Milner Teresa A
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Article Info
Journal
Brain research reviews
Abbr.
Brain Res Rev
ISSN
0165-0173
DOI
10.1016/j.brainresrev.2007.02.006
Email
[email protected]
Published
2007-10-00
Epub
2007-00-28
Pages
343-55
Language
English
Region
Netherlands
NLM ID
101300366
PMCID
PMC2101766
Subset
IM
Grants
NIDA NIH HHS · R01 DA008259-14 · United States
NIMH NIH HHS · R01 MH042834-12 · United States
NIMH NIH HHS · R37 MH041256 · United States
NHLBI NIH HHS · HL 18974 · United States
NINDS NIH HHS · R01 NS007080-39A2 · United States
NINDS NIH HHS · R01 NS007080 · United States
NINDS NIH HHS · NS 0007080 · United States
NHLBI NIH HHS · P01 HL018974-289002 · United States
NIDA NIH HHS · R01 DA008259-12 · United States
NIMH NIH HHS · MH 41256 · United States
NIDA NIH HHS · R01 DA008259 · United States
NHLBI NIH HHS · P01 HL018974 · United States
NIDA NIH HHS · R01 DA008259-13 · United States
NINDS NIH HHS · R01 NS007080-40 · United States
NINDS NIH HHS · R01 NS007080-38 · United States
NIDA NIH HHS · DA 08259 · United States
NIMH NIH HHS · R37 MH041256-18 · United States
NIDA NIH HHS · R01 DA008259-12S1 · United States
NHLBI NIH HHS · P01 HL018974-299002 · United States
NIMH NIH HHS · R01 MH041256 · United States
NINDS NIH HHS · R01 NS007080-37 · United States
NIDA NIH HHS · R01 DA008259-11A2 · United States
NHLBI NIH HHS · P01 HL018974-290022 · United States
NIMH NIH HHS · R37 MH041256-17 · United States
NHLBI NIH HHS · P01 HL018974-280022 · United States
External Links
PubMed source DOI: 10.1016/j.brainresrev.2007.02.006 PMC Full Text View journal details
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