Home LiteratureArticle Details
PMID: 17399883 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The IRF family, revisited.

Biochimie ·Vol. 89 ·No. 6-7 ·2007-00-00 ·Pages 744-53

Paun A, Pitha PM

Abstract

Since the discovery of interferon 50 years ago a great deal of progress has been made in understanding how interferons work and how and why they are induced. Key factors in interferon induction are the interferon regulatory factors (IRF). In this review of IRF we aim to show you not only the historical side of the IRF but also the integral, anti-viral and hematopoetic roles of these transcription factors, as well as the sometimes surprising and even forgotten roles that these proteins play, not only in interferon signaling but throughout the immune system and the body as a whole. Further research will no doubt expand the repertoire of these multifunctional proteins even more.

MeSH Terms
Animals Antiviral Agents/therapeutic use Hematopoiesis Humans Immune System Interferon Regulatory Factors/metabolism,physiology Interferons/metabolism,physiology Models, Biological Repressor Proteins/metabolism Response Elements Signal Transduction Transcription Factors/metabolism Viral Proteins/chemistry
Chemicals
Antiviral Agents Interferon Regulatory Factors Repressor Proteins Transcription Factors Viral Proteins Interferons
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Paun A
Division of Viral Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Pitha P M
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Article Info
Journal
Biochimie
Abbr.
Biochimie
ISSN
0300-9084
DOI
10.1016/j.biochi.2007.01.014
Published
2007-00-00
Epub
2007-00-20
Pages
744-53
Language
English
Region
France
NLM ID
1264604
PMCID
PMC2139905
Subset
IM
Grants
NIAID NIH HHS · R01 AI019737 · United States
NIAID NIH HHS · R01 AI019737-23 · United States
NIAID NIH HHS · R01 AI19737-19 · United States
External Links
PubMed source DOI: 10.1016/j.biochi.2007.01.014 PMC Full Text View journal details
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