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PMID: 174117 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types 1 and 2.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 2 ·1976-02-00 ·Pages 646-50

Hampar B, Aaronson SA, Derge JG, Chakrabarty M, Showalter SD, Dunn CY

Abstract

Infection of BALB/c mouse cells with UV-irradiated herpes simplex virus (HSV) types 1 and 2 resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat-inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3-4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

MeSH Terms
Cell Line Radiation Effects Retroviridae/growth & development Simplexvirus/radiation effects Ultraviolet Rays Virus Replication
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hampar B
Aaronson S A
Derge J G
Chakrabarty M
Showalter S D
Dunn C Y
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.2.646
Published
1976-02-00
Pages
646-50
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC335968
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.2.646 PMC Full Text View journal details
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