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PMID: 1742020 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease.

Neuron ·Vol. 7 ·No. 5 ·1991-11-00 ·Pages 695-702

Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW

Abstract

In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined by in situ hybridization. Hybridization signal for BDNF, but not NGF or NT-3, was decreased in samples of hippocampus from donors with AD. Decreased transcript abundance of BDNF mRNA in hippocampi of individuals with AD was verified by an RNAase protection assay. These results suggest the possibility that decreased expression of BDNF may contribute to the progression of cell death in AD.

MeSH Terms
Alzheimer Disease/genetics Brain-Derived Neurotrophic Factor Hippocampus/chemistry Humans Nerve Growth Factors/genetics Nerve Tissue Proteins/genetics Neurotrophin 3 Nucleic Acid Hybridization RNA, Messenger/analysis
Chemicals
Brain-Derived Neurotrophic Factor Nerve Growth Factors Nerve Tissue Proteins Neurotrophin 3 RNA, Messenger
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Phillips H S
Department of Developmental Biology, Genentech, South San Francisco, California 94080.
Hains J M
Armanini M
Laramee G R
Johnson S A
Winslow J W
Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/0896-6273(91)90273-3
Published
1991-11-00
Pages
695-702
Language
English
Region
United States
NLM ID
8809320
Subset
IM
External Links
PubMed source DOI: 10.1016/0896-6273(91)90273-3 View journal details
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